{"title":"控制神经元活动：α-突触核蛋白丝氨酸-129磷酸化在健康大脑中的新作用。","authors":"Danielle E. Mor","doi":"10.1016/j.tibs.2024.02.006","DOIUrl":null,"url":null,"abstract":"<div><p>Phosphorylation of α-synuclein protein at serine-129 (Ser129P) is a widely used marker for disease pathology in neurodegenerative disorders termed synucleinopathies. In groundbreaking work by <span>Parra-Rivas, Madhivanan <em>et al</em>.,</span><svg><path></path></svg> Ser129P was shown to facilitate the normal function of α-synuclein, bearing significant implications for the transition from a physiological to pathological state.</p></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 5","pages":"Pages 382-383"},"PeriodicalIF":11.6000,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Keeping neuronal activity in check: a novel role for α-synuclein serine-129 phosphorylation in the healthy brain\",\"authors\":\"Danielle E. Mor\",\"doi\":\"10.1016/j.tibs.2024.02.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Phosphorylation of α-synuclein protein at serine-129 (Ser129P) is a widely used marker for disease pathology in neurodegenerative disorders termed synucleinopathies. In groundbreaking work by <span>Parra-Rivas, Madhivanan <em>et al</em>.,</span><svg><path></path></svg> Ser129P was shown to facilitate the normal function of α-synuclein, bearing significant implications for the transition from a physiological to pathological state.</p></div>\",\"PeriodicalId\":440,\"journal\":{\"name\":\"Trends in Biochemical Sciences\",\"volume\":\"49 5\",\"pages\":\"Pages 382-383\"},\"PeriodicalIF\":11.6000,\"publicationDate\":\"2024-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Trends in Biochemical Sciences\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0968000424000513\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Biochemical Sciences","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0968000424000513","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Keeping neuronal activity in check: a novel role for α-synuclein serine-129 phosphorylation in the healthy brain
Phosphorylation of α-synuclein protein at serine-129 (Ser129P) is a widely used marker for disease pathology in neurodegenerative disorders termed synucleinopathies. In groundbreaking work by Parra-Rivas, Madhivanan et al., Ser129P was shown to facilitate the normal function of α-synuclein, bearing significant implications for the transition from a physiological to pathological state.
期刊介绍：
For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.
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