先天性 2 型细胞因子:从免疫调节到治疗目标。

IF 4.3 4区 医学 Q2 IMMUNOLOGY Immune Network Pub Date : 2024-01-31 eCollection Date: 2024-02-01 DOI:10.4110/in.2024.24.e6
Hye Young Kim, Dongjin Jeong, Ji Hyung Kim, Doo Hyun Chung
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引用次数: 0

摘要

先天性 2 型细胞因子在免疫反应中的作用错综复杂,越来越多的人认识到其双重性,既有保护作用,也有致病作用。从抵御寄生虫感染到导致哮喘、纤维化和肥胖等炎症性疾病,这些细胞因子与各种先天性免疫细胞错综复杂地相互作用。这篇综述细致地探讨了先天性 2 型细胞因子的细胞起源及其错综复杂的相互作用,揭示了 TSLP、IL-25 和 IL-33 等扩大先天性 2 型反应的因子。本文还讨论了治疗策略的最新进展,特别是针对关键细胞因子(IL-4、IL-5 和 IL-13)的生物制剂的使用,为我们提供了有关挑战和机遇的见解。认识到先天性 2 型细胞因子在协调免疫反应中的关键作用,将它们定位为有前景的治疗靶点。该领域不断发展的研究和开发成果不仅推动了免疫学知识的进步,也为未来更有效的治疗方法带来了希望。
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Innate Type-2 Cytokines: From Immune Regulation to Therapeutic Targets.

The intricate role of innate type-2 cytokines in immune responses is increasingly acknowledged for its dual nature, encompassing both protective and pathogenic dimensions. Ranging from defense against parasitic infections to contributing to inflammatory diseases like asthma, fibrosis, and obesity, these cytokines intricately engage with various innate immune cells. This review meticulously explores the cellular origins of innate type-2 cytokines and their intricate interactions, shedding light on factors that amplify the innate type-2 response, including TSLP, IL-25, and IL-33. Recent advancements in therapeutic strategies, specifically the utilization of biologics targeting pivotal cytokines (IL-4, IL-5, and IL-13), are discussed, offering insights into both challenges and opportunities. Acknowledging the pivotal role of innate type-2 cytokines in orchestrating immune responses positions them as promising therapeutic targets. The evolving landscape of research and development in this field not only propels immunological knowledge forward but also holds the promise of more effective treatments in the future.

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来源期刊
Immune Network
Immune Network Immunology and Microbiology-Immunology
CiteScore
2.90
自引率
3.30%
发文量
36
期刊介绍: Immune Network publishes novel findings in basic and clinical immunology and aims to provide a medium through which researchers in various fields of immunology can share and connect. The journal focuses on advances and insights into the regulation of the immune system and the immunological mechanisms of various diseases. Research that provides integrated insights into translational immunology is given preference for publication. All submissions are evaluated based on originality, quality, clarity, and brevity
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