SIRT1：肺部疾病关键调节途径的中间体

IF 5.1 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Laboratory Investigation Pub Date : 2024-03-05 DOI:10.1016/j.labinv.2024.102044

Yi-Zhu Jiang , Xin-Ran Huang , Jing Chang , Yong Zhou , Xiao-Ting Huang

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引用次数: 0

摘要

沉默信息调节因子 1 型（SIRT1）是一种依赖于烟酰胺腺嘌呤二核苷酸+（NAD+）的去乙酰化酶，是 sirtuins 家族的成员，具有独特的蛋白质去乙酰化酶活性。SIRT1 通过靶向多种蛋白质底物和信号参与生理和病理生理过程。在这篇综述中，我们介绍了 SIRT1 在肺部疾病中的最新研究进展。我们介绍了基本信息，并总结了 SIRT1 在几种肺部疾病（如急性肺损伤、急性呼吸窘迫综合征、慢性阻塞性肺病、肺癌和衰老相关疾病）中的突出作用。

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SIRT1: An Intermediator of Key Pathways Regulating Pulmonary Diseases

Silent information regulator type-1 (SIRT1), a nicotinamide adenine dinucleotide⁺-dependent deacetylase, is a member of the sirtuins family and has unique protein deacetylase activity. SIRT1 participates in physiological as well as pathophysiological processes by targeting a wide range of protein substrates and signalings. In this review, we described the latest progress of SIRT1 in pulmonary diseases. We have introduced the basic information and summarized the prominent role of SIRT1 in several lung diseases, such as acute lung injury, acute respiratory distress syndrome, chronic obstructive pulmonary disease, lung cancer, and aging-related diseases.

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来源期刊

Laboratory Investigation 医学-病理学

CiteScore

8.30

自引率

0.00%

发文量

125

审稿时长

2 months

期刊介绍： Laboratory Investigation is an international journal owned by the United States and Canadian Academy of Pathology. Laboratory Investigation offers prompt publication of high-quality original research in all biomedical disciplines relating to the understanding of human disease and the application of new methods to the diagnosis of disease. Both human and experimental studies are welcome.