Nuha A Alkhattabi, Fares K Khalifa, Huda A Al Doghaither, Ayat B Al-Ghafari, Nesrin Ibrahim Tarbiah, Aliaa Sabban
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引用次数: 0
摘要
研究目的本研究旨在探讨 S-腺苷-L-蛋氨酸（SAMe）与 N-乙酰半胱氨酸（NAC）相比对赭曲霉毒素 A（OTA）中毒的肾脏保护和免疫保护作用：将 48 只成年雄性 Sprague-Dawley 大鼠分为四组：对照组；赭曲霉毒素中毒组（每公斤食物含 5 毫克赭曲霉毒素）；赭曲霉毒素 + NAC 组（在喂食受赭曲霉毒素污染的平衡食物前，每天给大鼠喂食 200 毫克 NAC）；以及（赭曲霉毒素 + SAMe）。在喂食含有 OTA 的平衡膳食之前，大鼠口服溶解在蒸馏水中的 200 毫克 SAMe/天：结果：服用 OTA 会改变血清肾功能生物标志物。结果：服用 OTA 会改变血清中的肾功能生物标志物，而使用 NAC 则会明显减轻这些影响。结果表明，OTA 引起的免疫毒性与白细胞（WBC）数量减少之间存在相关性。结论：NAC和SAMe对白细胞计数和血红蛋白浓度有保护作用：结论：NAC 和 SAMe 对连续服用 OTA 引起的肾毒性和免疫毒性具有保护作用。结论：NAC 和 SAMe 对连续给药 OTA 引起的肾毒性和免疫毒性具有保护作用，NAC 在降低 OTA 肾毒性方面更有效，而 SAMe 在降低 OTA 免疫毒性方面比 NAC 更有效。
Protective effects of N-acetylcysteine and S-adenosyl-Lmethionine against nephrotoxicity and immunotoxicity induced by ochratoxin A in rats.
Objective: The present study was designed to investigate the nephroprotective and immunoprotective effects of S-adenosyl-L-methionine (SAMe) in comparison to N-acetylcysteine (NAC) against ochratoxin A (OTA) - intoxication.
Methods: Forty-eight adult male Sprague-Dawley rats were categorized into four groups: Control; OTA intoxication (5 mg OTA/kg diet); OTA + NAC, rats received 200 mg NAC/day before feeding balanced diet contaminated with OTA; and (OTA + SAMe). Rats received 200 mg SAMe/day dissolved in distilled water orally just before feeding a balanced diet contaminated with OTA.
Results: OTA administration altered serum kidney function biomarkers. These effects were pronouncedly alleviated by treatment with NAC. Results revealed a correlation between OTA-induced immunotoxicity and the reduced white blood cell (WBC) count. Treatments with SAMe significantly improved the WBCs count and hemoglobin concentration.
Conclusion: NAC and SAMe have a protective role against nephrotoxicity and immunotoxicity induced by continuous administration of OTA. NAC was more effective in reducing OTA nephrotoxicity, whereas SAMe was more potent than NAC in reducing OTA immunotoxicity.
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