Laís B Razza, Stefanie De Smet, Xander Cornelis, Stevan Nikolin, Matias M Pulopulos, Rudi De Raedt, Andre R Brunoni, Marie-Anne Vanderhasselt
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引用次数: 0
摘要
对前额叶皮层(PFC)的经颅直流电刺激(tDCS)通过自上而下的途径激活深层脑区,从而调节自律神经系统。然而,对神经系统的影响是多方面的,可能取决于电流的穿透量。因此,我们旨在研究 tDCS 对心率变异性(HRV)的不同影响,心率变异性是自律神经系统功能状态的一种测量指标。使用三种前额叶 tDCS 方案(1.5、3 mA 和假电流),我们将感兴趣脑区的模拟单个电场(E-field)大小与心率变异效应联系起来。这是一项随机、双盲、假对照和受试者内试验,健康的年轻成人参与者接受了 tDCS 治疗,治疗间隔为 2 周。研究对象的脑区包括背外侧前交叉皮层(DLPFC)、前扣带回皮层、脑岛和杏仁核。总共有 37 人接受了调查,相当于进行了 111 次 tDCS 治疗。研究结果表明,与假性和 1.5 mA 相比,3.0 mA tDCS 显著提高了心率变异(通过连续差值的均方根(RMSSD)和高频心率变异(HF-HRV)测量)。假性和 1.5 毫安之间没有差异。电场分析表明,所有感兴趣的脑区都与心率变异结果相关。然而,这种显著性与方案强度有关,而不是个体间大脑结构的可变性。总之,我们的研究结果表明,tDCS 对心率变异的影响具有剂量依赖性。因此,有必要进一步研究调节心率变异的最佳电流剂量。
Dose-dependent response of prefrontal transcranial direct current stimulation on the heart rate variability: An electric field modeling study.
Transcranial direct current stimulation (tDCS) of the prefrontal cortex (PFC) modulates the autonomic nervous system by activating deeper brain areas via top-down pathway. However, effects on the nervous system are heterogeneous and may depend on the amount of current that penetrates. Therefore, we aimed to investigate the variable effects of tDCS on heart rate variability (HRV), a measure of the functional state of the autonomic nervous system. Using three prefrontal tDCS protocols (1.5, 3 mA and sham), we associated the simulated individual electric field (E-field) magnitude in brain regions of interest with the HRV effects. This was a randomized, double-blinded, sham-controlled and within-subject trial, in which healthy young-adult participants received tDCS sessions separated by 2 weeks. The brain regions of interest were the dorsolateral PFC (DLPFC), anterior cingulate cortex, insula and amygdala. Overall, 37 participants were investigated, corresponding to a total of 111 tDCS sessions. The findings suggested that HRV, measured by root mean squared of successive differences (RMSSD) and high-frequency HRV (HF-HRV), were significantly increased by the 3.0 mA tDCS when compared to sham and 1.5 mA. No difference was found between sham and 1.5 mA. E-field analysis showed that all brain regions of interest were associated with the HRV outcomes. However, this significance was associated with the protocol intensity, rather than inter-individual brain structural variability. To conclude, our results suggest a dose-dependent effect of tDCS for HRV. Therefore, further research is warranted to investigate the optimal current dose to modulate HRV.
期刊介绍:
Founded in 1964, Psychophysiology is the most established journal in the world specifically dedicated to the dissemination of psychophysiological science. The journal continues to play a key role in advancing human neuroscience in its many forms and methodologies (including central and peripheral measures), covering research on the interrelationships between the physiological and psychological aspects of brain and behavior. Typically, studies published in Psychophysiology include psychological independent variables and noninvasive physiological dependent variables (hemodynamic, optical, and electromagnetic brain imaging and/or peripheral measures such as respiratory sinus arrhythmia, electromyography, pupillography, and many others). The majority of studies published in the journal involve human participants, but work using animal models of such phenomena is occasionally published. Psychophysiology welcomes submissions on new theoretical, empirical, and methodological advances in: cognitive, affective, clinical and social neuroscience, psychopathology and psychiatry, health science and behavioral medicine, and biomedical engineering. The journal publishes theoretical papers, evaluative reviews of literature, empirical papers, and methodological papers, with submissions welcome from scientists in any fields mentioned above.