治疗传染病的 RNA 疗法。

3区 生物学 Q2 Biochemistry, Genetics and Molecular Biology Progress in molecular biology and translational science Pub Date : 2024-01-01 Epub Date: 2024-01-29 DOI:10.1016/bs.pmbts.2024.01.002
Le Minh Tu Phan, Thi Thuy Duong Pham, Van Thai Than
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引用次数: 0

摘要

核糖核酸(RNA),包括信使核糖核酸(mRNA)、转移核糖核酸(tRNA)和核糖体核糖核酸(rRNA),在生物体和病毒中发挥着重要作用。近年来,以 RNA 为基础的技术,包括抑制其他 RNA 活性的 RNA、靶向蛋白质的 RNA、重编程遗传信息的 RNA 和编码治疗用蛋白质的 RNA,都是应用于预防和治疗疫苗的有用方法。在这篇综述中,我们总结并重点介绍了目前 RNA 疗法的应用,尤其是在预防和治疗人类和动物传染病方面具有潜力的 mRNA 疫苗。
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RNA therapeutics for infectious diseases.

Ribonucleic acids (RNAs), including the messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA), play important roles in living organisms and viruses. In recent years, the RNA-based technologies including the RNAs inhibiting other RNA activities, the RNAs targeting proteins, the RNAs reprograming genetic information, and the RNAs encoding therapeutical proteins, are useful methods to apply in prophylactic and therapeutic vaccines. In this review, we summarize and highlight the current application of the RNA therapeutics, especially on mRNA vaccines which have potential for prevention and treatment against human and animal infectious diseases.

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CiteScore
6.90
自引率
0.00%
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0
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>12 weeks
期刊介绍: Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientific importance. If today you read an Article or Letter in Nature or a Research Article or Report in Science reporting findings of exceptional importance, you likely will find comprehensive coverage of that research area in a future PMBTS volume.
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