年鳉鱼的免疫衰老。

IF 5.2 2区 医学 Q1 GERIATRICS & GERONTOLOGY Immunity & Ageing Pub Date : 2024-03-08 DOI:10.1186/s12979-024-00418-3
Gabriele Morabito, Alina Ryabova, Dario Riccardo Valenzano
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引用次数: 0

摘要

绿松石鳉鱼(Nothobranchius furzeri)的自然寿命很短,只有六个月左右,并表现出影响多个器官的衰老特征。这些特征包括蛋白质聚集、端粒缩短、细胞衰老和全身炎症。绿松石鳉鱼拥有脊椎动物特有的全套先天性和适应性免疫系统。然而,在最近的进化史中,它们失去了其他跃层鱼类所具有的粘膜特异性抗体同工酶亚型。随着年龄的增长,绿松石鳉鱼的免疫系统发生了巨大的细胞和系统性变化。这些变化包括炎症加剧、抗体多样性降低、肠道中病原微生物的流行率增加以及免疫祖细胞集群的 DNA 大面积损伤。总之,绿松石鳉鱼身上发生的一系列与年龄有关的变化表明,尽管在进化过程中,鱼类与哺乳动物之间存在着长达数亿年的分隔,但它们在免疫系统衰老方面却有着共同的特征。因此,在鳉鱼免疫系统中观察到的自发衰老为发现与脊椎动物免疫系统衰老相关的基本和保守方面提供了一个极好的机会。此外,该物种的自然寿命很短,只有几个月,而且容易进行实验,这为测试干预措施以改善整个机体与衰老相关的功能障碍提供了一个强大的平台,并有可能为开发基于免疫的治疗人类衰老相关疾病的方法提供信息。
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Immune aging in annual killifish.

Turquoise killifish (Nothobranchius furzeri) evolved a naturally short lifespan of about six months and exhibit aging hallmarks that affect multiple organs. These hallmarks include protein aggregation, telomere shortening, cellular senescence, and systemic inflammation. Turquoise killifish possess the full spectrum of vertebrate-specific innate and adaptive immune system. However, during their recent evolutionary history, they lost subsets of mucosal-specific antibody isoforms that are present in other teleosts. As they age, the immune system of turquoise killifish undergoes dramatic cellular and systemic changes. These changes involve increased inflammation, reduced antibody diversity, an increased prevalence of pathogenic microbes in the intestine, and extensive DNA damage in immune progenitor cell clusters. Collectively, the wide array of age-related changes occurring in turquoise killifish suggest that, despite an evolutionary separation spanning hundreds of millions of years, teleosts and mammals share common features of immune system aging. Hence, the spontaneous aging observed in the killifish immune system offers an excellent opportunity for discovering fundamental and conserved aspects associated with immune system aging across vertebrates. Additionally, the species' naturally short lifespan of only a few months, along with its experimental accessibility, offers a robust platform for testing interventions to improve age-related dysfunctions in the whole organism and potentially inform the development of immune-based therapies for human aging-related diseases.

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来源期刊
Immunity & Ageing
Immunity & Ageing GERIATRICS & GERONTOLOGY-IMMUNOLOGY
CiteScore
10.20
自引率
3.80%
发文量
55
期刊介绍: Immunity & Ageing is a specialist open access journal that was first published in 2004. The journal focuses on the impact of ageing on immune systems, the influence of aged immune systems on organismal well-being and longevity, age-associated diseases with immune etiology, and potential immune interventions to increase health span. All articles published in Immunity & Ageing are indexed in the following databases: Biological Abstracts, BIOSIS, CAS, Citebase, DOAJ, Embase, Google Scholar, Journal Citation Reports/Science Edition, OAIster, PubMed, PubMed Central, Science Citation Index Expanded, SCImago, Scopus, SOCOLAR, and Zetoc.
期刊最新文献
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