装载纳米抗菌剂的纳米微胶囊可长期抑制耐药菌株

IF 0.7 4区 材料科学 Q3 Materials Science Materials Express Pub Date : 2024-03-01 DOI:10.1166/mex.2024.2570
Ke He, Fu Pengjiazi, Yanqi Wu, Yanting He, Qing Hu, Jia Wu, Guangxun Cui, Jun Zhang, Jun Jin
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引用次数: 0

摘要

人们对公共设施和设备的安全越来越关注和担忧。因此,具有抗菌性能的涂料产品成为解决这一问题的关键,开发新型抗菌建筑涂料迫在眉睫。本研究以苯乙烯为原料制备了聚苯乙烯纳米微球(PS NMS)。以 PS NMS 为模板,采用溶质共扩散法(SCM)制备了 PS 纳米微胶囊(PS NMC),并对其进行改性,得到 PS-OH NMC。进一步负载具有抗菌活性的 CuS 纳米粒子(CuS NPs),制备出具有长期抗菌活性的 CuS@PS-OH NMC。扫描电镜结果表明,CuS@PS-OH NMC 的粒径约为 410 nm,大于 PS-OH NMC 的粒径。紫外光谱和红外光谱的表征证实,CuS NPs 不仅被大量包裹在 PS NMC 中,而且还少量附着在其表面。CuS@PS-OH NMC 具有良好的水溶性,能缓慢释放 Cu2+,对耐甲氧西林金黄色葡萄球菌(MRSA)具有良好的长期抗菌性能。本研究开发的 CuS@PS-OH NMC 具有性能优异、抗菌效果好、环境友好、价格低廉等特点。更重要的是,它能长期有效地抑制 MRSA,可作为一种潜在的抗菌建筑涂料,用于医院、学校和人口密集场所等特殊场景,具有很好的社会和经济价值。
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Nano-microcapsules loaded with nano-antibacterial agents for long-term inhibition of drug-resistant strains
There are growing concerns and worries about the safety of public facilities and equipment. Therefore, coating products with antibacterial properties have become the key to solve this problem, and there is an urgent need to develop new antibacterial architectural coatings. In this study, polystyrene nano-microspheres (PS NMS) were prepared from styrene as raw material. PS nano-microcapsules (PS NMC) were prepared by solute co-diffusion method (SCM) using PS NMS as a template, which were modified to obtain PS-OH NMC. CuS nanoparticles (CuS NPs) with antibacterial activity were further loaded to prepare CuS@PS-OH NMC with long-term antibacterial activity. The SEM results showed that the particle size of CuS@PS-OH NMC was about 410 nm, which was larger than that of PS-OH NMC. The characterization of UV and IR spectra confirmed that CuS NPs were not only encapsulated into PS NMC in large quantities, but also adhered to its surface in a small amount. CuS@PS-OH NMC has good water solubility and can slowly release Cu2+, showing good long-term antibacterial properties against Methicillin-resistant Staphylococcus aureus (MRSA). The CuS@PS-OH NMC developed in this study has excellent performance, good antibacterial effect, environmental friendliness, low price, etc. More importantly, it can efficiently and long-term inhibit MRSA, and can be used as a potential antibacterial architectural coating for special scenarios such as hospitals, schools and densely populated places, which has excellent social and economic value.
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Materials Express
Materials Express NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY
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