长达十年的洞察力:追踪意大利巴勒莫曾接触石棉的工人中与石棉相关的健康影响。

IF 1.5 Q3 HEALTH CARE SCIENCES & SERVICES Annali di igiene : medicina preventiva e di comunita Pub Date : 2024-09-01 Epub Date: 2024-03-07 DOI:10.7416/ai.2024.2619
Claudio Costantino, Caterina Ledda, Matteo Riccò, Eduardo Costagliola, Francesco Balsamo, Miriam Belluzzo, Nicole Bonaccorso, Alessandro Carubia, Luciano D'Azzo, Martina Sciortino, Tania Vitello, Luigi Zagra, Santo Fruscione, Sara Ilardo, Elisa Trapani, Giuseppe Calamusa, Venerando Rapisarda, Walter Mazzucco
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引用次数: 0

摘要

背景:石棉是全球最主要的职业致癌物。尽管第 257/1992 号法律禁止使用石棉,但意大利仍然是欧洲国家中患石棉相关疾病(ARDs)最多的国家之一。这项研究评估了 2010-2021 年期间意大利巴勒莫省接触石棉工人的 ARD 病例:数据采集利用了巴勒莫地方卫生局(LHA)预防部下属的 "工作环境预防和安全服务 "的流行病学数据集:结果:2010 年至 2021 年间,我们共发现了 245 例急性放射损伤病例,其中包括 163 例石棉沉滞症/胸膜斑、41 例肺癌、38 例间皮瘤和 3 例不明病例。多变量分析表明,相对于胸膜斑块/石棉沉着病,间皮瘤(HR=0.933;95% CI=0.902-0.965)和肺癌(HR=0.93;95% CI=0.90-0.978)的时间暴露显著下降。吸烟与肺癌有明显的相关性(吸烟者 HR=64.520 95% CI=13,075-318.390;曾经吸烟者 HR=20.917 95% CI=4,913-89.048)。在受雇于造船和修船业的人群中,间皮瘤与胸膜斑块/石棉沉着病之间存在明显联系(HR=0.371 95% CI=0.155-0.892):结论:即使在 1992 年停止与石棉有关的活动之后,ARD 在临床观察中依然存在,这凸显了公共卫生面临的持久挑战。加强预防策略至关重要,重点是扩大异常和职业数据的收集,从而促进对职业暴露人群中这些疾病的早期诊断策略。
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Decade-long insights: tracking asbestos-related health impacts among formerly exposed workers in Palermo, Italy.

Background: Asbestos is a foremost occupational carcinogen globally. Despite the prohibition under Law 257/1992, Italy persists as one of the European nations most burdened by asbestos-related diseases (ARDs). This research assessed ARD cases in asbestos-exposed workers from the Province of Palermo, Italy, spanning 2010-2021.

Methods: Data acquisition utilized the epidemiological dataset from the 'Service of Prevention and Safety on Work Environment' under the Prevention Department of Palermo's Local Health Authority (LHA).

Results: Between 2010 and 2021, we identified 245 ARD instances, comprising 163 Asbestosis/Pleural plaques, 41 Lung Cancers, 38 Mesotheliomas, and 3 unspecified cases. Multivariate analysis indicated a notable decline in temporal exposure for mesothelioma (HR=0.933; 95% CI=0.902-0.965) and lung cancer (HR=0.93; 95% CI=0.90-0.978) relative to pleural plaques/asbestosis. Tobacco use displayed a pronounced correlation with lung cancer (smoker HR=64.520 95% CI=13,075-318.390; former smoker HR=20.917 95% CI=4,913-89.048). A significant link was observed between mesothelioma and pleural plaques/asbestosis in those employed in shipbuilding and repair (HR=0.371 95% CI=0.155-0.892).

Conclusions: ARDs persist in clinical observations, even following the 1992 cessation of asbestos-related activities, emphasizing an enduring public health challenge. Enhancing prevention strategies is paramount, focusing on amplifying anamnestic and occupational data collection, thereby facilitating superior early diagnosis strategies for these maladies in the occupationally exposed cohort.

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来源期刊
Annali di igiene : medicina preventiva e di comunita
Annali di igiene : medicina preventiva e di comunita HEALTH CARE SCIENCES & SERVICES-
CiteScore
3.40
自引率
0.00%
发文量
69
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