A A Garganeeva, E A Kuzheleva, O V Tukish, M Yu Kondratiev, K N Vitt, S L Andreev, O N Ogurkova
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In addition to routine clinical laboratory tests, coagulation parameters were evaluated and the following inflammatory biomarkers were determined: neutrophil gelatinase-associated lipocalin (NGAL), growth/differentiation factor 15 (GDF-15), fibroblast growth factor 23 (FGF-23), transforming growth factor beta-1 (TGF-β1), and high-sensitivity C-reactive protein. Also, the calculated neutrophil-to-lymphocyte ratio (N LR) was included in the analysis. Follow-up duration was at least 12 months (median 16 [13, 22] months). Statistical analysis of the data was performed with the IBM SPSS Statistics 21 software.</p><p><strong>Results: </strong>The study presented results of a factor analysis of 10 inflammatory biomarkers in patients who were scheduled for CABG. 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引用次数: 0
摘要
目的：研究慢性心力衰竭（CHF）和狭窄性多血管冠状动脉粥样硬化患者炎症生物标志物的预后意义，并确定在前瞻性观察期间反映亚临床炎症并与心血管并发症发展相关的生物标志物独立集：该研究纳入了80名患有慢性心力衰竭和缺血性心脏病并计划在住院期间接受冠状动脉旁路移植术（CABG）的患者。除常规临床实验室检查外，还评估了凝血参数，并测定了以下炎症生物标志物：中性粒细胞明胶酶相关脂质体（NGAL）、生长/分化因子 15（GDF-15）、成纤维细胞生长因子 23（FGF-23）、转化生长因子β-1（TGF-β1）和高敏 C 反应蛋白。此外，计算得出的中性粒细胞与淋巴细胞比率（N LR）也被纳入分析范围。随访时间至少为 12 个月（中位数为 16 [13, 22] 个月）。数据统计分析采用 IBM SPSS Statistics 21 软件进行：结果：该研究对计划接受心血管造影术的患者的 10 种炎症生物标志物进行了因子分析。分析确定的因素之一包括冠状动脉粥样硬化狭窄的 CHF 患者血液中的 NGAL 和 GDF-15 水平、N LR 和纤维蛋白原水平，并且与前瞻性观察期间的死亡率显著相关。此外，即使对年龄、肾小球滤过率、心脏和冠状动脉功能不全的严重程度以及是否患有糖尿病等因素进行调整后，这种相关性仍然显著：结论：在慢性心力衰竭合并冠状动脉狭窄的患者中，一组炎症标志物（包括血液中的 NGAL、GDF-15、N LR 和纤维蛋白原）可合并成一个反映亚临床炎症的因子。该因子的值可用于预测外科心肌血运重建术后的长期心血管死亡。
[Biomarkers of Inflammation in Predicting the Outcomes of Heart Failure of Ischemic Etiology: the Results of Factor Analysis].
Aim: To study the prognostic significance of inflammatory biomarkers in patients with chronic heart failure (CHF) and stenotic multivessel coronary atherosclerosis, with determination of the biomarker separate set that reflects subclinical inflammation and is associated with the development of cardiovascular complications during prospective observation.
Material and methods: A prospective observational study was conducted that included 80 patients with CHF and ischemic heart disease who were scheduled for coronary artery bypass grafting (CABG) during their current hospitalization. In addition to routine clinical laboratory tests, coagulation parameters were evaluated and the following inflammatory biomarkers were determined: neutrophil gelatinase-associated lipocalin (NGAL), growth/differentiation factor 15 (GDF-15), fibroblast growth factor 23 (FGF-23), transforming growth factor beta-1 (TGF-β1), and high-sensitivity C-reactive protein. Also, the calculated neutrophil-to-lymphocyte ratio (N LR) was included in the analysis. Follow-up duration was at least 12 months (median 16 [13, 22] months). Statistical analysis of the data was performed with the IBM SPSS Statistics 21 software.
Results: The study presented results of a factor analysis of 10 inflammatory biomarkers in patients who were scheduled for CABG. One of the factors identified by the analysis included the levels of NGAL and GDF-15, N LR, and the level of fibrinogen in the blood in CHF patients with stenotic coronary atherosclerosis and was significantly associated with the death rate during prospective observation. Furthermore, this association remained significant even after adjustments for age, glomerular filtration rate, severity of heart and coronary insufficiency, and the presence of diabetes mellitus.
Conclusion: In patients with CHF and stenotic coronary atherosclerosis, a set of inflammatory markers, including blood NGAL, GDF-15, N LR, and fibrinogen, can be combined into one factor reflecting subclinical inflammation. The value of this factor can be used to predict cardiovascular death in the long term after surgical myocardial revascularization.
期刊介绍：
“Kardiologiya” (Cardiology) is a monthly scientific, peer-reviewed journal committed to both basic cardiovascular medicine and practical aspects of cardiology.
As the leader in its field, “Kardiologiya” provides original coverage of recent progress in cardiovascular medicine. We publish state-of-the-art articles integrating clinical and research activities in the fields of basic cardiovascular science and clinical cardiology, with a focus on emerging issues in cardiovascular disease. Our target audience spans a diversity of health care professionals and medical researchers working in cardiovascular medicine and related fields.
The principal language of the Journal is Russian, an additional language – English (title, authors’ information, abstract, keywords).
“Kardiologiya” is a peer-reviewed scientific journal. All articles are reviewed by scientists, who gained high international prestige in cardiovascular science and clinical cardiology. The Journal is currently cited and indexed in major Abstracting & Indexing databases: Web of Science, Medline and Scopus.
The Journal''s primary objectives
Contribute to raising the professional level of medical researchers, physicians and academic teachers.
Present the results of current research and clinical observations, explore the effectiveness of drug and non-drug treatments of heart disease, inform about new diagnostic techniques; discuss current trends and new advancements in clinical cardiology, contribute to continuing medical education, inform readers about results of Russian and international scientific forums;
Further improve the general quality of reviewing and editing of manuscripts submitted for publication;
Provide the widest possible dissemination of the published articles, among the global scientific community;
Extend distribution and indexing of scientific publications in major Abstracting & Indexing databases.
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