DNA 甲基化标记鉴定和多甲基化风险评分在预测健康寿命终止中的作用。

IF 3 4区医学 Q2 GENETICS & HEREDITY Epigenomics Pub Date : 2024-04-01 Epub Date: 2024-03-14 DOI:10.2217/epi-2023-0343

Meiqi Yang, Mei Wang, Xiaoyu Zhao, Feifei Xu, Shuang Liang, Yifan Wang, Nanxi Wang, Muhammed Lamin Sambou, Yue Jiang, Juncheng Dai

{"title":"DNA 甲基化标记鉴定和多甲基化风险评分在预测健康寿命终止中的作用。","authors":"Meiqi Yang, Mei Wang, Xiaoyu Zhao, Feifei Xu, Shuang Liang, Yifan Wang, Nanxi Wang, Muhammed Lamin Sambou, Yue Jiang, Juncheng Dai","doi":"10.2217/epi-2023-0343","DOIUrl":null,"url":null,"abstract":"Aim: To elucidate the epigenetic consequences of DNA methylation in healthspan termination (HST), considering the current limited understanding. Materials & methods: Genetically predicted DNA methylation models were established (n = 2478). These models were applied to genome-wide association study data on HST. Then, a poly-methylation risk score (PMRS) was established in 241,008 individuals from the UK Biobank. Results: Of the 63,046 CpGs from the prediction models, 13 novel CpGs were associated with HST. Furthermore, people with high PMRSs showed higher HST risk (hazard ratio: 1.18; 95% CI: 1.13-1.25). Conclusion: The study indicates that DNA methylation may influence HST by regulating the expression of genes (e.g., PRMT6, CTSK). PMRSs have a promising application in discriminating subpopulations to facilitate early prevention.","PeriodicalId":11959,"journal":{"name":"Epigenomics","volume":" ","pages":"461-472"},"PeriodicalIF":3.0000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"DNA methylation marker identification and poly-methylation risk score in prediction of healthspan termination.\",\"authors\":\"Meiqi Yang, Mei Wang, Xiaoyu Zhao, Feifei Xu, Shuang Liang, Yifan Wang, Nanxi Wang, Muhammed Lamin Sambou, Yue Jiang, Juncheng Dai\",\"doi\":\"10.2217/epi-2023-0343\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Aim: To elucidate the epigenetic consequences of DNA methylation in healthspan termination (HST), considering the current limited understanding. Materials & methods: Genetically predicted DNA methylation models were established (n = 2478). These models were applied to genome-wide association study data on HST. Then, a poly-methylation risk score (PMRS) was established in 241,008 individuals from the UK Biobank. Results: Of the 63,046 CpGs from the prediction models, 13 novel CpGs were associated with HST. Furthermore, people with high PMRSs showed higher HST risk (hazard ratio: 1.18; 95% CI: 1.13-1.25). Conclusion: The study indicates that DNA methylation may influence HST by regulating the expression of genes (e.g., PRMT6, CTSK). PMRSs have a promising application in discriminating subpopulations to facilitate early prevention.\",\"PeriodicalId\":11959,\"journal\":{\"name\":\"Epigenomics\",\"volume\":\" \",\"pages\":\"461-472\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2024-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Epigenomics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2217/epi-2023-0343\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/3/14 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"GENETICS & HEREDITY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Epigenomics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2217/epi-2023-0343","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/3/14 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}

引用次数: 0

摘要

目的：考虑到目前对 DNA 甲基化在健康终结（HST）中的表观遗传学影响的了解有限，旨在阐明其在健康终结中的影响。材料与方法建立遗传预测 DNA 甲基化模型（n = 2478）。这些模型被应用于有关 HST 的全基因组关联研究数据。然后，在英国生物库的 241 008 个个体中建立了多甲基化风险评分（PMRS）。结果显示在预测模型得出的 63046 个 CpGs 中，有 13 个新的 CpGs 与 HST 相关。此外，PMRS 较高的人显示出更高的 HST 风险（危险比：1.18；95% CI：1.13-1.25）。结论研究表明，DNA甲基化可能会通过调节基因（如 PRMT6、CTSK）的表达来影响 HST。PMRS 在区分亚群以促进早期预防方面具有广阔的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

DNA methylation marker identification and poly-methylation risk score in prediction of healthspan termination.

Aim: To elucidate the epigenetic consequences of DNA methylation in healthspan termination (HST), considering the current limited understanding. Materials & methods: Genetically predicted DNA methylation models were established (n = 2478). These models were applied to genome-wide association study data on HST. Then, a poly-methylation risk score (PMRS) was established in 241,008 individuals from the UK Biobank. Results: Of the 63,046 CpGs from the prediction models, 13 novel CpGs were associated with HST. Furthermore, people with high PMRSs showed higher HST risk (hazard ratio: 1.18; 95% CI: 1.13-1.25). Conclusion: The study indicates that DNA methylation may influence HST by regulating the expression of genes (e.g., PRMT6, CTSK). PMRSs have a promising application in discriminating subpopulations to facilitate early prevention.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Epigenomics GENETICS & HEREDITY-

CiteScore

5.80

自引率

2.60%

发文量

审稿时长

>12 weeks

期刊介绍： Epigenomics provides the forum to address the rapidly progressing research developments in this ever-expanding field; to report on the major challenges ahead and critical advances that are propelling the science forward. The journal delivers this information in concise, at-a-glance article formats – invaluable to a time constrained community. Substantial developments in our current knowledge and understanding of genomics and epigenetics are constantly being made, yet this field is still in its infancy. Epigenomics provides a critical overview of the latest and most significant advances as they unfold and explores their potential application in the clinical setting.