脑内低级别胶质瘤疾病对健康相关生活质量的纵向影响。

IF 1.3 4区 医学 Q4 CLINICAL NEUROLOGY Journal of neurosurgical sciences Pub Date : 2024-03-14 DOI:10.23736/S0390-5616.23.06107-6
Laurèl Rauschenbach, Pauline Bartsch, Alejandro N Santos, Anna Michel, Hanah H Gull, Pikria Ketelauri, Marvin Darkwah Oppong, Börge Schmidt, Celia Dobersalske, Tobias Blau, Yahya Ahmadipour, Ramazan Jabbarli, Karsten H Wrede, Ulrich Sure, Philipp Dammann
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引用次数: 0

摘要

背景本研究旨在评估脑内低级别胶质瘤治疗前后的健康相关生活质量(HRQOL):2012年至2018年期间接受手术切除肿瘤的低级别胶质瘤患者符合本研究的条件。所有患者及其近亲均接受了全面的术前检查:根据 2021 年世界卫生组织中枢神经系统肿瘤分类进行调整后,共有 25 名患者被转介作进一步分析。与健康参考人群的数值相比,患者在治疗前后的多个 SF36 项目中均表现出明显的局限性。在治疗过程中,SF36项目没有明显变化,但ALQI问卷显示,随着时间的推移,患者的HRQOL有所下降。亲属提供的数据与患者的评分结果高度一致。单变量分析表明,神经功能恶化和癫痫持续发作是一年后患者HRQOL不佳的预测因素:结论:低级别胶质瘤疾病对患者的 HRQOL 有重大影响,治疗可能会导致患者的 HRQOL 进一步恶化。新出现的神经功能缺损和持续的癫痫发作是生活质量受限的预测因素。由于这些结果是基于一个随访时间有限的小群体得出的,因此这些说法的推广性有限,还需要进一步的研究。
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Longitudinal impact of intracerebral low-grade glioma disease on health-related quality of life.

Background: The aim of this study was to assess health-related quality of life (HRQOL) before and after treatment for intracerebral low-grade glioma.

Methods: Patients with low-grade glioma who underwent surgical tumor removal between 2012 and 2018 were eligible for this study. All individuals and their closest relatives received thorough preoperative (

Results: A total of 25 patients were referred for further analysis, after adjustment to the 2021 WHO classification for central nervous system tumors. Compared to the values of a healthy reference population, the patients expressed significant limitations in several SF36 items, both before and after treatment. Under treatment, there were no significant changes in the SF36 items, but the ALQI questionnaire indicated decreasing HRQOL over time. Data derived from relatives revealed a high degree of concordance with the rating results of the patients. Univariate analysis identified neurological deterioration and ongoing epileptic seizures as predictors for unfavorable HRQOL after one year.

Conclusions: Low-grade glioma disease has a significant impact on HRQOL and treatment might contribute to further deterioration. New-onset neurological deficits and ongoing epileptic seizures are predictors of limitations in quality of life. Since the results are based on a small cohort with limited follow-up time, the generalizability of these statements is limited and further studies are required.

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来源期刊
Journal of neurosurgical sciences
Journal of neurosurgical sciences CLINICAL NEUROLOGY-SURGERY
CiteScore
3.00
自引率
5.30%
发文量
202
审稿时长
>12 weeks
期刊介绍: The Journal of Neurosurgical Sciences publishes scientific papers on neurosurgery and related subjects (electroencephalography, neurophysiology, neurochemistry, neuropathology, stereotaxy, neuroanatomy, neuroradiology, etc.). Manuscripts may be submitted in the form of ditorials, original articles, review articles, special articles, letters to the Editor and guidelines. The journal aims to provide its readers with papers of the highest quality and impact through a process of careful peer review and editorial work.
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