确定 KLOTHO 和 ARNTL 基因的 DNA 甲基化状态与高血压的关系

IF 0.5 4区 医学 Q4 GENETICS & HEREDITY Balkan Journal of Medical Genetics Pub Date : 2024-03-12 eCollection Date: 2023-12-01 DOI:10.2478/bjmg-2023-0024
M Osum, O Tosun, H Birtan, R Kalkan
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引用次数: 0

摘要

高血压是一种多因素慢性疾病,是环境因素与遗传改变相互作用的结果。KLOTHO和ARNTL基因在高血压的发病中起着重要作用。因此,我们利用甲基化敏感高分辨率熔解技术(MSHRM)分析了 78 名高血压患者和 49 名对照组患者 KLOTHO 和 ARNTL 基因的甲基化状态。在这项研究中,我们未能发现 KLOTHO 和 ARNTL 甲基化与高血压表型之间存在显著关联。此外,我们也没有发现 KLOTHO 和 ARNTL 甲基化与高血压患者的空腹血糖、甘油三酯、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、钠(Na)、肌酐(Cr)、钾(K)和尿素水平有直接关系。然而,我们发现甲基化的 KLOTHO 高血压患者与未甲基化的 KLOTHO 对照组之间在钾(K)方面存在明显差异。
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Determination of the Relationship Between DNA Methylation Status of KLOTHO and ARNTL Genes With Hypertension.

Hypertension is a multifactorial chronic disease due to the interaction of environmental factors with genetic alteration. KLOTHO and ARNTL genes play an important role in the development of hypertension. Therefore, we analyzed the methylation status of KLOTHO and ARNTL genes by using methylation-sensitive high-resolution melting (MSHRM) in a total of 78 hypertensive and 49 control subjects. In this study, we could not identify a significant association between KLOTHO and ARNTL methylation and the hypertensive phenotype. Moreover, we could not find a direct association between KLOTHO and ARNTL methylation and the fasting blood sugar, triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol, sodium (Na), creatinine (Cr), potassium (K), and urea levels in hypertensive patients. However, we found a significant difference between the methylated KLOTHO hypertensive patients and the unmethylated KLOTHO control subjects for potassium (K).

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来源期刊
CiteScore
1.00
自引率
0.00%
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0
审稿时长
>12 weeks
期刊介绍: Balkan Journal of Medical Genetics is a journal in the English language for publication of articles involving all branches of medical genetics: human cytogenetics, molecular genetics, clinical genetics, immunogenetics, oncogenetics, pharmacogenetics, population genetics, genetic screening and diagnosis of monogenic and polygenic diseases, prenatal and preimplantation genetic diagnosis, genetic counselling, advances in treatment and prevention.
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