确定 KLOTHO 和 ARNTL 基因的 DNA 甲基化状态与高血压的关系

IF 0.5 4区 医学 Q4 GENETICS & HEREDITY Balkan Journal of Medical Genetics Pub Date : 2024-03-12 eCollection Date: 2023-12-01 DOI:10.2478/bjmg-2023-0024
M Osum, O Tosun, H Birtan, R Kalkan
{"title":"确定 KLOTHO 和 ARNTL 基因的 DNA 甲基化状态与高血压的关系","authors":"M Osum, O Tosun, H Birtan, R Kalkan","doi":"10.2478/bjmg-2023-0024","DOIUrl":null,"url":null,"abstract":"<p><p>Hypertension is a multifactorial chronic disease due to the interaction of environmental factors with genetic alteration. <i>KLOTHO</i> and <i>ARNTL</i> genes play an important role in the development of hypertension. Therefore, we analyzed the methylation status of <i>KLOTHO</i> and <i>ARNTL</i> genes by using methylation-sensitive high-resolution melting (MSHRM) in a total of 78 hypertensive and 49 control subjects. In this study, we could not identify a significant association between <i>KLOTHO</i> and <i>ARNTL</i> methylation and the hypertensive phenotype. Moreover, we could not find a direct association between <i>KLOTHO</i> and <i>ARNTL</i> methylation and the fasting blood sugar, triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol, sodium (Na), creatinine (Cr), potassium (K), and urea levels in hypertensive patients. However, we found a significant difference between the methylated <i>KLOTHO</i> hypertensive patients and the unmethylated <i>KLOTHO</i> control subjects for potassium (K).</p>","PeriodicalId":55403,"journal":{"name":"Balkan Journal of Medical Genetics","volume":"26 2","pages":"41-50"},"PeriodicalIF":0.5000,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10932598/pdf/","citationCount":"0","resultStr":"{\"title\":\"Determination of the Relationship Between DNA Methylation Status of <i>KLOTHO</i> and <i>ARNTL</i> Genes With Hypertension.\",\"authors\":\"M Osum, O Tosun, H Birtan, R Kalkan\",\"doi\":\"10.2478/bjmg-2023-0024\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Hypertension is a multifactorial chronic disease due to the interaction of environmental factors with genetic alteration. <i>KLOTHO</i> and <i>ARNTL</i> genes play an important role in the development of hypertension. Therefore, we analyzed the methylation status of <i>KLOTHO</i> and <i>ARNTL</i> genes by using methylation-sensitive high-resolution melting (MSHRM) in a total of 78 hypertensive and 49 control subjects. In this study, we could not identify a significant association between <i>KLOTHO</i> and <i>ARNTL</i> methylation and the hypertensive phenotype. Moreover, we could not find a direct association between <i>KLOTHO</i> and <i>ARNTL</i> methylation and the fasting blood sugar, triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol, sodium (Na), creatinine (Cr), potassium (K), and urea levels in hypertensive patients. However, we found a significant difference between the methylated <i>KLOTHO</i> hypertensive patients and the unmethylated <i>KLOTHO</i> control subjects for potassium (K).</p>\",\"PeriodicalId\":55403,\"journal\":{\"name\":\"Balkan Journal of Medical Genetics\",\"volume\":\"26 2\",\"pages\":\"41-50\"},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2024-03-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10932598/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Balkan Journal of Medical Genetics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2478/bjmg-2023-0024\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/12/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"GENETICS & HEREDITY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Balkan Journal of Medical Genetics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2478/bjmg-2023-0024","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/12/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 0

摘要

高血压是一种多因素慢性疾病,是环境因素与遗传改变相互作用的结果。KLOTHO和ARNTL基因在高血压的发病中起着重要作用。因此,我们利用甲基化敏感高分辨率熔解技术(MSHRM)分析了 78 名高血压患者和 49 名对照组患者 KLOTHO 和 ARNTL 基因的甲基化状态。在这项研究中,我们未能发现 KLOTHO 和 ARNTL 甲基化与高血压表型之间存在显著关联。此外,我们也没有发现 KLOTHO 和 ARNTL 甲基化与高血压患者的空腹血糖、甘油三酯、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、钠(Na)、肌酐(Cr)、钾(K)和尿素水平有直接关系。然而,我们发现甲基化的 KLOTHO 高血压患者与未甲基化的 KLOTHO 对照组之间在钾(K)方面存在明显差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Determination of the Relationship Between DNA Methylation Status of KLOTHO and ARNTL Genes With Hypertension.

Hypertension is a multifactorial chronic disease due to the interaction of environmental factors with genetic alteration. KLOTHO and ARNTL genes play an important role in the development of hypertension. Therefore, we analyzed the methylation status of KLOTHO and ARNTL genes by using methylation-sensitive high-resolution melting (MSHRM) in a total of 78 hypertensive and 49 control subjects. In this study, we could not identify a significant association between KLOTHO and ARNTL methylation and the hypertensive phenotype. Moreover, we could not find a direct association between KLOTHO and ARNTL methylation and the fasting blood sugar, triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol, sodium (Na), creatinine (Cr), potassium (K), and urea levels in hypertensive patients. However, we found a significant difference between the methylated KLOTHO hypertensive patients and the unmethylated KLOTHO control subjects for potassium (K).

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
1.00
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: Balkan Journal of Medical Genetics is a journal in the English language for publication of articles involving all branches of medical genetics: human cytogenetics, molecular genetics, clinical genetics, immunogenetics, oncogenetics, pharmacogenetics, population genetics, genetic screening and diagnosis of monogenic and polygenic diseases, prenatal and preimplantation genetic diagnosis, genetic counselling, advances in treatment and prevention.
期刊最新文献
ANXA5 and VEGFA Gene Variants in Women with Early Pregnancy Losses from North Macedonia. Comparison of FGF-8, FGF-10, FGF-Receptor 2, Androgen Receptor, Estrogen Receptor-A and SS in Healthy and Hypospadiac Children. High-Resolution HLA-DRB1 Allele Frequencies in a Romanian Cohort of Stem Cell Donors. IGHV Mutational Status in a Cohort of Bulgarian CLL Patients: High Unmutated CLL Prevalence in North-East Bulgaria. Meaning and Clinical Interest of Minor Malformations and Normal Variants in Neonatology.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1