沙特阿拉伯利雅得某医疗城对抗精神病药物诱发的高泌乳素血症的监测和管理方法评估:一项回顾性队列研究。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-03-12 DOI:10.2174/0115748863280407240305070905
Zahra Hussain Alshabeeb, Bashayr Alsuwayni, Omar Alshargi, Ahmed H. Abdelazeem
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引用次数: 0

摘要

背景:高催乳素血症是抗精神病药物常见的一种被低估的不良反应。对于最佳的监测和治疗策略,目前还没有达成共识的指导方针:本研究旨在评估抗精神病药物诱发的高泌乳素血症的监测和治疗方法,以及与之相关的发病率和风险因素:从 2020 年 5 月至 2021 年 5 月,在沙特阿拉伯利雅得一家学术性三级医院的精神科门诊就诊的患者中开展了一项回顾性队列观察研究,查阅了每位患者长达五年的病历:在 662 名患者中,分别有 35 名患者(5.3%)和 242 名患者(36.6%)接受了血清催乳素水平监测(分别在基线和随访时)。212名患者(32%)出现了高催乳素血症。只有 76 名患者(36%)有症状。女性、年轻和躁狂症患者患高催乳素血症的风险明显更高。60%的确诊病例接受了治疗,其中76人(60%)遵守了治疗指南。最常见的治疗策略是减少剂量(42.5%)和增加阿立哌唑剂量(29.1%):结论:在开始任何抗精神病药物治疗之前,必须对催乳素水平进行基线检查。结论:在开始任何抗精神病药物治疗之前,都必须进行催乳素水平的基线检查。同样,建议对接受可能具有催乳素升高作用的抗精神病药物治疗的患者进行常规催乳素水平监测,无论其症状如何。遵守循证治疗指南可以提高患者的生活质量和治疗依从性。
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Assessment of Monitoring and Management Practices of Antipsychotic-Induced Hyperprolactinemia at a Medical City in Riyadh, Saudi Arabia: A Retrospective Cohort Study.

Background: Hyperprolactinemia is a commonly underestimated adverse effect of antipsychotic medications. There are still no consensus guidelines for the optimal monitoring and treatment strategies.

Objective: The aim of the study was to assess the monitoring and treatment practices of antipsychotic-induced hyperprolactinemia, in addition to the prevalence and risk factors associated with it.

Methods: A retrospective cohort observational study was conducted among patients attending the psychiatric clinics at an academic tertiary hospital in Riyadh, Saudi Arabia, from May 2020 until May 2021, by reviewing each patient's medical record for up to five years.

Results: Among the 662 patients, 35 patients (5.3%) and 242 patients (36.6%) had their serum prolactin levels monitored (at baseline and at follow-up, respectively). The prevalence of hyperprolactinemia was observed in 212 patients (32%). Only 76 patients (36%) were symptomatic. Female gender, younger age, and bipolar disorder had a significantly higher risk of developing hyperprolactinemia. 60% of the confirmed cases received treatment, of which 76 (60%) were adherent to treatment guidelines. The most common treatment strategies implemented were dose reduction (42.5%) and aripiprazole augmentation (29.1%).

Conclusion: It is imperative to conduct a baseline check of prolactin levels before commencing any antipsychotic therapy. Similarly, routine prolactin level monitoring is recommended regardless of symptoms in patients treated with antipsychotics with a possible prolactin-raising effect. Adherence to evidence-based treatment guidelines can improve patient quality of life and therapeutic compliance.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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