Charlotte Eposse Ekoube, Dora Mbonjo Bitsie, Erero F Njiengwe, Edgar Mandeng Ma Linwa, Christian Eyoum, Ritha Mbono Betoko, Jeannette Disso Massako, Emmanuel Heles Nsang, Abba Soumaiyatou, Callixte Tegueu Kuate
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Our study aimed to compare the QoL between caregivers of children and adolescents with SCD and HIV and explore factors associated with this QoL in Cameroon.</p><p><strong>Methods and materials: </strong>We conducted a hospital-based cross-sectional analytic study at Douala Laquintinie Hospital from February to May 2023. A questionnaire was administered to caregivers of paediatric patients (≤18 years) with SCD and HIV. The Pediatrics Quality of Life-Family Impact Module (PedsQL FIM), the 7-item Generalized Anxiety Disorder (GAD-7), and the 9-item Patient Health Question (PHQ-9) tools were used as measures of quality of life, anxiety, and depression, respectively. Multivariable linear regression was used to determine factors associated with quality of life. A significance level was set at <i>p</i> < 0.05.</p><p><strong>Results: </strong>We included 199 caregivers: SCD = 104 and HIV = 95. The mean age of caregivers in our sample was 40.47 ± 10.18 years. Caregivers of paediatric patients with HIV had a better mean quality of life than SCD (93.01 ± 7.35SD versus 64.86 ± 9.20SD, <i>p</i> < 0.001). PHQ-9 score (<i>B</i> = -1.52, 95% CI = [-2.08; -0.96], <i>p</i>=<0.001), GAD-7 score (<i>B</i> = -1.46, 95% CI = [-2.09; -0.83], <i>p</i>=<0.001), spending less than 75 000 FCFA on medications monthly (<i>B</i> = 12.13, 95% CI = [5.73; 18.94], <i>p</i>=<0.001), and being a SCD caregiver (<i>B</i> = -11.62, 95% CI = [-18.46; -4.78], <i>p</i>=0.001) were factors independently associated with quality of life on multivariable analysis.</p><p><strong>Conclusion: </strong>Quality of life is lower in caregivers of children and adolescents with SCD than with HIV. Preventing depression and anxiety as well as advocating for the subsidization of medications through a national SCD program may improve quality of life in SCD caregivers.</p>","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2024 ","pages":"4429541"},"PeriodicalIF":2.2000,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10937083/pdf/","citationCount":"0","resultStr":"{\"title\":\"Exploring Factors Associated with Quality of Life in Caregivers of Children and Adolescents with Sickle Cell Disease and HIV: A Comparative Analysis.\",\"authors\":\"Charlotte Eposse Ekoube, Dora Mbonjo Bitsie, Erero F Njiengwe, Edgar Mandeng Ma Linwa, Christian Eyoum, Ritha Mbono Betoko, Jeannette Disso Massako, Emmanuel Heles Nsang, Abba Soumaiyatou, Callixte Tegueu Kuate\",\"doi\":\"10.1155/2024/4429541\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Paediatric HIV and sickle cell disease (SCD) are two stigmatising and potentially fatal illnesses that place a significant burden on families. HIV patients benefit from a longstanding free-service national programme in Cameroon, and this could considerably alleviate burden of care on HIV caregivers, possibly leading to better quality of life (QoL) in HIV caregivers compared to SCD caregivers. Our study aimed to compare the QoL between caregivers of children and adolescents with SCD and HIV and explore factors associated with this QoL in Cameroon.</p><p><strong>Methods and materials: </strong>We conducted a hospital-based cross-sectional analytic study at Douala Laquintinie Hospital from February to May 2023. A questionnaire was administered to caregivers of paediatric patients (≤18 years) with SCD and HIV. The Pediatrics Quality of Life-Family Impact Module (PedsQL FIM), the 7-item Generalized Anxiety Disorder (GAD-7), and the 9-item Patient Health Question (PHQ-9) tools were used as measures of quality of life, anxiety, and depression, respectively. Multivariable linear regression was used to determine factors associated with quality of life. A significance level was set at <i>p</i> < 0.05.</p><p><strong>Results: </strong>We included 199 caregivers: SCD = 104 and HIV = 95. The mean age of caregivers in our sample was 40.47 ± 10.18 years. Caregivers of paediatric patients with HIV had a better mean quality of life than SCD (93.01 ± 7.35SD versus 64.86 ± 9.20SD, <i>p</i> < 0.001). PHQ-9 score (<i>B</i> = -1.52, 95% CI = [-2.08; -0.96], <i>p</i>=<0.001), GAD-7 score (<i>B</i> = -1.46, 95% CI = [-2.09; -0.83], <i>p</i>=<0.001), spending less than 75 000 FCFA on medications monthly (<i>B</i> = 12.13, 95% CI = [5.73; 18.94], <i>p</i>=<0.001), and being a SCD caregiver (<i>B</i> = -11.62, 95% CI = [-18.46; -4.78], <i>p</i>=0.001) were factors independently associated with quality of life on multivariable analysis.</p><p><strong>Conclusion: </strong>Quality of life is lower in caregivers of children and adolescents with SCD than with HIV. Preventing depression and anxiety as well as advocating for the subsidization of medications through a national SCD program may improve quality of life in SCD caregivers.</p>\",\"PeriodicalId\":46055,\"journal\":{\"name\":\"Anemia\",\"volume\":\"2024 \",\"pages\":\"4429541\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2024-03-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10937083/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Anemia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/2024/4429541\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"HEMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Anemia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2024/4429541","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"HEMATOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
导言：儿科艾滋病和镰状细胞病（SCD）是两种令人耻辱且可能致命的疾病，给家庭带来沉重负担。在喀麦隆，HIV 患者受益于一项长期免费服务的国家计划，这可以大大减轻 HIV 护理人员的护理负担，与 SCD 护理人员相比，可能会提高 HIV 护理人员的生活质量（QoL）。我们的研究旨在比较喀麦隆 SCD 和 HIV 儿童和青少年患者护理者的 QoL，并探讨与 QoL 相关的因素：我们于 2023 年 2 月至 5 月在杜阿拉 Laquintinie 医院进行了一项基于医院的横断面分析研究。我们对 SCD 和 HIV 儿童患者（≤18 岁）的护理人员进行了问卷调查。儿科生活质量-家庭影响模块（PedsQL FIM）、7 个项目的广泛性焦虑症（GAD-7）和 9 个项目的患者健康问题（PHQ-9）工具分别被用作生活质量、焦虑和抑郁的测量工具。多变量线性回归用于确定与生活质量相关的因素。显著性水平设定为 p < 0.05：我们纳入了 199 名护理人员：SCD=104人，HIV=95人。样本中照顾者的平均年龄为 40.47 ± 10.18 岁。儿科艾滋病患者的护理人员的平均生活质量高于 SCD 患者（93.01 ± 7.35SD 对 64.86 ± 9.20SD，P < 0.001）。PHQ-9评分（B=-1.52，95% CI=[-2.08；-0.96]，P=B=-1.46，95% CI=[-2.09；-0.83]，P=B=12.13，95% CI=[5.73；18.94]，P=B=-11.62，95% CI=[-18.46；-4.78]，P=0.001）是多变量分析中与生活质量独立相关的因素：结论：SCD 儿童和青少年患者的照顾者的生活质量低于 HIV 患者。预防抑郁和焦虑以及通过国家 SCD 计划倡导药物补贴可提高 SCD 护理人员的生活质量。
Exploring Factors Associated with Quality of Life in Caregivers of Children and Adolescents with Sickle Cell Disease and HIV: A Comparative Analysis.
Introduction: Paediatric HIV and sickle cell disease (SCD) are two stigmatising and potentially fatal illnesses that place a significant burden on families. HIV patients benefit from a longstanding free-service national programme in Cameroon, and this could considerably alleviate burden of care on HIV caregivers, possibly leading to better quality of life (QoL) in HIV caregivers compared to SCD caregivers. Our study aimed to compare the QoL between caregivers of children and adolescents with SCD and HIV and explore factors associated with this QoL in Cameroon.
Methods and materials: We conducted a hospital-based cross-sectional analytic study at Douala Laquintinie Hospital from February to May 2023. A questionnaire was administered to caregivers of paediatric patients (≤18 years) with SCD and HIV. The Pediatrics Quality of Life-Family Impact Module (PedsQL FIM), the 7-item Generalized Anxiety Disorder (GAD-7), and the 9-item Patient Health Question (PHQ-9) tools were used as measures of quality of life, anxiety, and depression, respectively. Multivariable linear regression was used to determine factors associated with quality of life. A significance level was set at p < 0.05.
Results: We included 199 caregivers: SCD = 104 and HIV = 95. The mean age of caregivers in our sample was 40.47 ± 10.18 years. Caregivers of paediatric patients with HIV had a better mean quality of life than SCD (93.01 ± 7.35SD versus 64.86 ± 9.20SD, p < 0.001). PHQ-9 score (B = -1.52, 95% CI = [-2.08; -0.96], p=<0.001), GAD-7 score (B = -1.46, 95% CI = [-2.09; -0.83], p=<0.001), spending less than 75 000 FCFA on medications monthly (B = 12.13, 95% CI = [5.73; 18.94], p=<0.001), and being a SCD caregiver (B = -11.62, 95% CI = [-18.46; -4.78], p=0.001) were factors independently associated with quality of life on multivariable analysis.
Conclusion: Quality of life is lower in caregivers of children and adolescents with SCD than with HIV. Preventing depression and anxiety as well as advocating for the subsidization of medications through a national SCD program may improve quality of life in SCD caregivers.
期刊介绍：
Anemia is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies on all types of anemia. Articles focusing on patient care, health systems, epidemiology, and animal models will be considered, among other relevant topics. Affecting roughly one third of the world’s population, anemia is a major public health concern. The journal aims to facilitate the exchange of research addressing global health and mortality relating to anemia and associated diseases.
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