中国北方 1 型糖尿病患儿视网膜神经纤维层的早期变化。

IF 1.3 4区医学 Q4 ENDOCRINOLOGY & METABOLISM Journal of Pediatric Endocrinology & Metabolism Pub Date : 2024-03-18 Print Date: 2024-04-25 DOI:10.1515/jpem-2023-0446

Dejing Wu, Rongxiu Zheng, Xuan Kan, Liping Hao, Ying Wei, Jie Cao

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引用次数: 0

摘要

研究目的本研究旨在确定中国北方无视网膜病变的1型糖尿病（T1DM）儿童与健康受试者之间视网膜神经纤维层（RNFL）的差异：这是一项以医院为基础的横断面研究，于2019年1月至2021年7月在天津医科大学总医院儿科开展。对患有T1DM但无视网膜疾病的儿童进行筛查。通过光谱域光学相干断层扫描获得RNFL厚度。此外，还收集了病程、HbA1c、25-羟维生素D水平、胰岛素方案和饮食控制状况：结果：共招募了 20 名 T1DM 患儿和 20 名匹配的健康参与者。T1DM 组的平均年龄为 10.3±2.8 岁，中位糖尿病病程为 1 年（1-3 年不等）。与对照组相比，T1DM 患儿的平均 RNFL 更薄（105 ± 6 vs. 110 ± 11 μm，p=0.008），尤其是在颞部和鼻部。在 T1DM 组中，HbA1c 水平与 RNFL 厚度之间存在明显的负相关（B（95 % 置信区间）：-4.313（-7.0 % 置信区间）：-结论：在我们的研究中，T1DM 早期儿童的 RNFL 厚度下降与 HbA1c 升高呈负相关。

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Early change of retinal nerve fiber layer in children with type 1 diabetes mellitus in northern China.

Objectives: This study aimed to identify discrepancies in the retinal nerve fiber layer (RNFL) between type 1 diabetes mellitus (T1DM) children without retinopathy and healthy subjects in northern China.

Methods: This was a cross-sectional hospital-based study carried out from Jan 2019 until Jul 2021 at the department of pediatrics in Tianjin medical university general hospital. Children with T1DM but no retinal disease were screened. RNFL thickness was obtained via spectral domain optical coherence tomography. Disease duration, HbA_1c, 25-hydroxyvitamin D level, insulin regimen, and diet control status were also collected.

Results: A total of 20 children with T1DM and 20 matched health participants were enrolled. The mean age in the T1DM group was 10.3 ± 2.8 years, and the median duration of diabetes was 1 (range 1-3) year. Children with T1DM had thinner average RNFL than control subjects (105 ± 6 vs. 110 ± 11 μm, p=0.008), especially in temporal and nasal parts. There was a significant negative association between HbA_1c levels and the RNFL thickness in the T1DM group (B (95 % confidence interval): -4.313 (-7.055 to -1.571); p=0.005).

Conclusions: In our study, the decreased thickness of RNFL was negatively associated with elevated HbA_1c in children with early stages of T1DM.

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来源期刊

Journal of Pediatric Endocrinology & Metabolism 医学-内分泌学与代谢

CiteScore

2.70

自引率

7.10%

发文量

176

审稿时长

3-6 weeks

期刊介绍： The aim of the Journal of Pediatric Endocrinology and Metabolism (JPEM) is to diffuse speedily new medical information by publishing clinical investigations in pediatric endocrinology and basic research from all over the world. JPEM is the only international journal dedicated exclusively to endocrinology in the neonatal, pediatric and adolescent age groups. JPEM is a high-quality journal dedicated to pediatric endocrinology in its broadest sense, which is needed at this time of rapid expansion of the field of endocrinology. JPEM publishes Reviews, Original Research, Case Reports, Short Communications and Letters to the Editor (including comments on published papers),. JPEM publishes supplements of proceedings and abstracts of pediatric endocrinology and diabetes society meetings.