第 3 组先天性淋巴细胞训练有素的守门员

IF 7.5 2区 医学 Q1 IMMUNOLOGY Immunological Reviews Pub Date : 2024-03-16 DOI:10.1111/imr.13322
Nicolas Serafini, James P. Di Santo
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引用次数: 0

摘要

第 3 组先天性淋巴细胞(ILC3s)是组织驻留免疫淋巴细胞,对肠道稳态、器官生成和免疫起着至关重要的调节作用。ILC3 具有 "感知 "组织内炎症环境的能力,尤其是在病原体挑战的背景下,这种挑战会在 ILC3 功能中留下持久的非抗原特异性变化的印记。因此,ILC3s 成为训练有素的先天性免疫这一新兴领域的新角色。在此,我们总结了最近发现的 ILC3 对细菌挑战的反应,以及这些遭遇在触发训练有素的先天性免疫中所起的作用。我们进一步讨论了信号事件如何在整个 ILC3 本体发育过程中潜在地控制训练有素的 ILC3 的发育和功能。最后,我们强调了围绕 ILC3 "训练 "的开放性问题,这些问题的答案可能会揭示先天性免疫的新见解。了解训练有素的先天性免疫背后的基本概念,有可能开发出新的策略,改善基于免疫的炎症、传染病和癌症调节疗法。
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Group 3 innate lymphoid cells: A trained Gutkeeper

Group 3 innate lymphoid cells (ILC3s) are tissue-resident immune lymphocytes that critically regulate intestinal homeostasis, organogenesis, and immunity. ILC3s possess the capacity to “sense” the inflammatory environment within tissues, especially in the context of pathogen challenges that imprints durable non-antigen-specific changes in ILC3 function. As such, ILC3s become a new actor in the emerging field of trained innate immunity. Here, we summarize recent discoveries regarding ILC3 responses to bacterial challenges and the role these encounters play in triggering trained innate immunity. We further discuss how signaling events throughout ILC3 ontogeny potentially control the development and function of trained ILC3s. Finally, we highlight the open questions surrounding ILC3 “training” the answers to which may reveal new insights into innate immunity. Understanding the fundamental concepts behind trained innate immunity could potentially lead to the development of new strategies for improving immunity-based modulation therapies for inflammation, infectious diseases, and cancer.

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来源期刊
Immunological Reviews
Immunological Reviews 医学-免疫学
CiteScore
16.20
自引率
1.10%
发文量
118
审稿时长
4-8 weeks
期刊介绍: Immunological Reviews is a specialized journal that focuses on various aspects of immunological research. It encompasses a wide range of topics, such as clinical immunology, experimental immunology, and investigations related to allergy and the immune system. The journal follows a unique approach where each volume is dedicated solely to a specific area of immunological research. However, collectively, these volumes aim to offer an extensive and up-to-date overview of the latest advancements in basic immunology and their practical implications in clinical settings.
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