用磷脂酰乙醇识别疑似重伤患者长期过度饮酒--IDART 研究的结果。

IF 2.1 4区 医学 Q3 SUBSTANCE ABUSE Alcohol and alcoholism Pub Date : 2024-03-16 DOI:10.1093/alcalc/agae014
Benedicte M Jørgenrud, Camilla C Bråthen, Jo Steinson Stenehjem, Thomas Kristiansen, Leiv Arne Rosseland, Stig Tore Bogstrand
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引用次数: 0

摘要

引言急性和慢性饮酒是众所周知的事故和伤害风险因素,同时使用精神活性药物会进一步增加伤害风险。磷脂酰乙醇(PEth)16:0/18:1是一种生物标志物,用于确定前3-4周的饮酒量。该研究旨在通过磷脂酰乙醇(PEth)16:0/18:1的浓度确定外伤患者长期饮酒的普遍程度,以及过度长期饮酒与人口统计学变量、受伤机制和药物使用之间的关系:研究对象:2019年3月至2020年2月期间在挪威创伤医院接受治疗的患者。该研究是作为创伤性损伤风险因素的损害性药物和酒精研究的一部分:所有年龄≥16岁、在创伤团队接受治疗的患者均纳入研究。登记受伤日期和机制、性别和年龄等数据。对血液样本中的 22 种精神药物和违禁药物、乙醇和磷脂酰乙醇 16:0/18:1 进行分析。进行了回归分析,以评估酒精使用与性别、年龄、受伤机制和药物使用之间的关联:在研究的 4845 名患者中,10% 的患者 PEth 16:0/18:1 浓度≥ 600 nM(约 430 ng/mL),这表明患者长期过度饮酒。男性、44-61岁、参与暴力事件、药物检测呈阳性与长期过度饮酒有关。长期过度饮酒常见于男性、中年、以暴力为伤害机制的患者和使用药物的患者。这些发现强调了发现和治疗创伤患者长期过度饮酒的必要性。
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Identifying excessive chronic alcohol use with phosphatidylethanol in patients with suspected severe injury-results from the IDART study.

Introduction: Acute and chronic alcohol use are well-known risk factors for accidents and injuries, and concurrent psychoactive drug use can increase injury risk further. Phosphatidylethanol (PEth) 16:0/18:1 is a biomarker used to determine alcohol consumption the previous 3-4 weeks. The aim was to investigate the prevalence of chronic alcohol use in trauma patients, as determined by PEth 16:0/18:1 concentrations, and how excessive chronic alcohol use relate to demographic variables, injury mechanisms and drug use.

Setting: Patients received at Norwegian trauma hospitals from March 2019 to February 2020. The study is part of the Impairing Drugs and Alcohol as Risk factors for Traumatic Injuries study.

Methods: All patients aged ≥ 16 years received with trauma team were included in the study. Data on injury date and mechanism, gender and age was registered. Blood samples were analyzed for 22 psychoactive medicinal and illicit drugs, ethanol and phosphatidylethanol 16:0/18:1. Regression analyses were conducted to assess associations between alcohol use and gender, age, injury mechanism and drug use.

Results and conclusion: Of the 4845 patients included in the study, 10% had PEth 16:0/18:1 concentration ≥ 600 nM (~430 ng/mL), indicative of excessive chronic alcohol use. Being male, between 44-61 years old, involved in violence, and testing positive for medicinal drugs was associated with excessive chronic alcohol use.Excessive chronic alcohol use was common among males, middle-aged, patients with violence as injury mechanism and those with medicinal drug use. These findings emphasize the need to detect and treat excessive chronic alcohol use among trauma patients.

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来源期刊
Alcohol and alcoholism
Alcohol and alcoholism 医学-药物滥用
CiteScore
4.70
自引率
3.60%
发文量
62
审稿时长
4-8 weeks
期刊介绍: About the Journal Alcohol and Alcoholism publishes papers on the biomedical, psychological, and sociological aspects of alcoholism and alcohol research, provided that they make a new and significant contribution to knowledge in the field. Papers include new results obtained experimentally, descriptions of new experimental (including clinical) methods of importance to the field of alcohol research and treatment, or new interpretations of existing results. Theoretical contributions are considered equally with papers dealing with experimental work provided that such theoretical contributions are not of a largely speculative or philosophical nature.
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