牙周炎患者唾液 Il-38 水平的评估:一项横断面研究

IF 1.9 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Interferon and Cytokine Research Pub Date : 2024-03-18 DOI:10.1089/jir.2023.0233
Ayşe Toraman, Ebru Sağlam, Levent Savran, Serhat Köseoğlu
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引用次数: 0

摘要

本研究旨在评估各种牙周临床状况下唾液白细胞介素 (IL)-38、IL-1β 和 IL-10 的水平。研究共纳入了 60 名受试者(20 名健康受试者、20 名牙龈炎受试者和 20 名 II-III 期 A-B 级牙周炎受试者)。研究人员记录了受试者的人口统计学和牙周临床参数。通过酶联免疫吸附试验检测样本中的 IL-38、IL-1β 和 IL-10 水平。结果表明,牙周炎组唾液 IL-38 水平明显低于健康组(P < 0.05)。唾液 IL-10 水平在各组间无明显差异(P > 0.05)。牙龈炎组(P < 0.001)和牙周炎组(P < 0.01)的唾液 IL-1β 水平明显高于健康组。本研究表明,牙周病患者的 IL-38 水平降低。结果表明,IL-38 在牙周炎症过程中可能发挥作用。阐明 IL-38 在炎症过程中的作用机制可能有助于开发新的牙周病治疗策略。
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Evaluation of Salivary Il-38 Levels in Periodontitis: A Cross-Sectional Study.

The goal of the current study was to assess levels of salivary interleukin (IL)-38, IL-1β, and IL-10 in various periodontal clinical conditions. In total, 60 (20 healthy, 20 gingivitis, and 20 stage II-III, grade A-B periodontitis) subjects were included in the study. Demographic and clinical periodontal parameters were recorded. Samples were examined for IL-38, IL-1β, and IL-10 levels by means of enzyme-linked immunosorbent assay. Results demonstrated that the periodontitis group had significantly lower salivary IL-38 levels (P < 0.05) than the healthy group. Salivary IL-10 levels did not differ significantly between the groups (P > 0.05). The salivary IL-1β levels of gingivitis (P < 0.001) and periodontitis groups (P < 0.01) were significantly higher than those of the healthy group. The present study indicated that IL-38 level is decreased in periodontal disease. The results suggested a possible role of IL-38 in the periodontal inflammation process. Clarifying the mechanisms of IL-38 in the inflammatory process may contribute to the development of novel treatment strategies in periodontal diseases.

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来源期刊
CiteScore
3.80
自引率
0.00%
发文量
78
审稿时长
2.2 months
期刊介绍: Journal of Interferon & Cytokine Research (JICR) provides the latest groundbreaking research on all aspects of IFNs and cytokines. The Journal delivers current findings on emerging topics in this niche community, including the role of IFNs in the therapy of diseases such as multiple sclerosis, the understanding of the third class of IFNs, and the identification and function of IFN-inducible genes.
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