主观听力损失与认知障碍之间的关联和潜在多重机制

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引用次数: 0

摘要

摘要 背景 主观听力损失(SHL)是指个人对其听力损失的自我评估。SHL与认知障碍之间的关联和潜在机制仍有待阐明。 目标 验证 SHL 与认知障碍之间的潜在机制。 设计 横断面。 地点 中国上海。 参与者 来自社区和认知障碍诊所的 2369 人。 测量 对所有参与者进行全面的神经心理学评估,包括老年人听力障碍量表筛查版(HHIE-S)。此外,还收集了参与者的大脑β淀粉样蛋白(Aβ)沉积状况、与阿尔茨海默病(AD)相关的血浆生物标志物以及心血管风险因素。 结果 在 SHL 增高的个体中,HHIE-S 评分的升高与认知和日常功能减退以及抑郁情绪水平升高有关。在听觉记忆表现中可以观察到这种相关性,但在视觉记忆中却观察不到。SHL对认知功能的影响是由抑郁情绪介导的。SHL与糖尿病和吸烟有关,而认知功能则与高脂血症和饮酒有关。在脑Aβ沉积阳性的个体中,SHL与认知功能的关系不受血浆Aβ42/40比率、P-tau181、神经丝轻链和APOE等位基因状态的影响。 结论 SHL 对认知障碍有独立影响。研究结果没有为共同病因机制提供证据。相反,研究结果支持认知资源机制和贫困环境机制的存在,以及病理相互作用机制的可能性。
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Associations and Potential Multiple Mechanisms between Subjective Hearing Loss and Cognitive Impairment

Abstract

Background

Subjective hearing loss (SHL) refers to an individual’s self-assessment of their hearing loss. The association and underlying mechanisms between SHL and cognitive impairment still necessitate elucidation.

Objectives

To validate potential mechanisms between SHL and cognitive impairment.

Design

Cross-section.

Setting

Shanghai, China.

Participants

A total of 2369 individuals from communities and the cognitive disorder clinic.

Measurements

All participants were subjected to a comprehensive neuropsychological assessment, encompassing the Hearing Handicap Inventory for the Elderly-Screening Version (HHIE-S). The participants’ brain β-amyloid (Aβ) deposition status, plasma biomarkers associated with Alzheimer’s disease (AD), and cardiovascular risk factors were also collected.

Results

In individuals with a heightened SHL, elevated HHIE-S score was linked to diminished cognitive and daily functioning as well as heightened levels of depressed mood. This correlation was observed in auditory memory performance but not in visual memory. The influence of SHL on cognitive function was mediated by depressed mood. SHL was associated with diabetes and smoking, whereas cognitive function was associated with hyperlipidemia and alcohol consumption. In individuals with positive brain Aβ deposition, SHL demonstrated associations with cognitive function independent of plasma Aβ42/40 ratio, P-tau181, neurofilament light chain, and APOE allele status.

Conclusion

SHL has an independent effect on cognitive impairment. The findings do no provide evidence for the common cause mechanism. Instead, the findings support the presence of a cognitive resource mechanism and an impoverished environment mechanism, along with the potential for a pathological interaction mechanism.

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来源期刊
The Journal of Prevention of Alzheimer's Disease
The Journal of Prevention of Alzheimer's Disease Medicine-Psychiatry and Mental Health
CiteScore
9.20
自引率
0.00%
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0
期刊介绍: The JPAD Journal of Prevention of Alzheimer’Disease will publish reviews, original research articles and short reports to improve our knowledge in the field of Alzheimer prevention including: neurosciences, biomarkers, imaging, epidemiology, public health, physical cognitive exercise, nutrition, risk and protective factors, drug development, trials design, and heath economic outcomes.JPAD will publish also the meeting abstracts from Clinical Trial on Alzheimer Disease (CTAD) and will be distributed both in paper and online version worldwide.We hope that JPAD with your contribution will play a role in the development of Alzheimer prevention.
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