Filippo Nozzoli , Martina Catalano , Luca Messerini , Fabio Cianchi , Romina Nassini , Francesco De Logu , Luigi Francesco Iannone , Filippo Ugolini , Sara Simi , Daniela Massi , Pierangelo Geppetti , Giandomenico Roviello
{"title":"胰腺癌切除术患者神经周围侵犯评分系统与临床预后","authors":"Filippo Nozzoli , Martina Catalano , Luca Messerini , Fabio Cianchi , Romina Nassini , Francesco De Logu , Luigi Francesco Iannone , Filippo Ugolini , Sara Simi , Daniela Massi , Pierangelo Geppetti , Giandomenico Roviello","doi":"10.1016/j.pan.2024.03.004","DOIUrl":null,"url":null,"abstract":"<div><h3>Background/objectives</h3><p>Perineural invasion (PNI), classified according to its presence or absence in tumor specimens, is recognized as a poor prognostic factor in pancreatic ductal adenocarcinoma (PDAC) patients. Herein, we identified five histological features of PNI and investigated their impact on survival outcomes of PDAC resected patients.</p></div><div><h3>Methods</h3><p>Five histopathological features of PNI (diameter, number, site, sheath involvement, and mitotic figures within perineural invasion) were combined in an additional final score (ranging from 0 to 8), and clinical data of PDAC patients were retrospectively analyzed. PNI + patients were stratified in two categories according to the median score value (<6 and ≥ 6, respectively). Impact of PNI on disease-free survival (DFS) and overall survival (OS) were analyzed.</p></div><div><h3>Results</h3><p>Forty-five patients were enrolled, of whom 34 with PNI (PNI+) and 11 without PNI (PNI-). The DFS was 11 months <em>vs.</em> not reached (NR) (<em>p</em> = 0.258), while the OS was 19 months <em>vs.</em> NR (<em>p</em> = 0.040) in PNI+ and PNI- patients, respectively. A ≥6 PNI was identified as an independent predictor of worse OS <em>vs.</em> <6 PNI + patients (29 <em>vs.</em> 11 months, <em>p</em> < 0.001) and <6 PNI+ and PNI- patients (43 <em>vs.</em> 11 months, <em>p</em> < 0.001). PNI ≥6 was an independent negative prognostic factor of DFS <em>vs</em>. <6 PNI+ and PNI- patients (13 <em>vs</em>. 6 months, <em>p</em> = 0.022).</p></div><div><h3>Conclusions</h3><p>We report a PNI scoring system that stratifies surgically-treated PDAC patients in a graded manner that correlates with patient prognosis better than the current dichotomous (presence/absence) definition. However, further and larger studies are needed to support this PNI scoring system.</p></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":null,"pages":null},"PeriodicalIF":2.8000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1424390324000656/pdfft?md5=ddf8711744afb64ae0a897b4531c38cf&pid=1-s2.0-S1424390324000656-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Perineural invasion score system and clinical outcomes in resected pancreatic cancer patients\",\"authors\":\"Filippo Nozzoli , Martina Catalano , Luca Messerini , Fabio Cianchi , Romina Nassini , Francesco De Logu , Luigi Francesco Iannone , Filippo Ugolini , Sara Simi , Daniela Massi , Pierangelo Geppetti , Giandomenico Roviello\",\"doi\":\"10.1016/j.pan.2024.03.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background/objectives</h3><p>Perineural invasion (PNI), classified according to its presence or absence in tumor specimens, is recognized as a poor prognostic factor in pancreatic ductal adenocarcinoma (PDAC) patients. Herein, we identified five histological features of PNI and investigated their impact on survival outcomes of PDAC resected patients.</p></div><div><h3>Methods</h3><p>Five histopathological features of PNI (diameter, number, site, sheath involvement, and mitotic figures within perineural invasion) were combined in an additional final score (ranging from 0 to 8), and clinical data of PDAC patients were retrospectively analyzed. PNI + patients were stratified in two categories according to the median score value (<6 and ≥ 6, respectively). Impact of PNI on disease-free survival (DFS) and overall survival (OS) were analyzed.</p></div><div><h3>Results</h3><p>Forty-five patients were enrolled, of whom 34 with PNI (PNI+) and 11 without PNI (PNI-). The DFS was 11 months <em>vs.</em> not reached (NR) (<em>p</em> = 0.258), while the OS was 19 months <em>vs.</em> NR (<em>p</em> = 0.040) in PNI+ and PNI- patients, respectively. A ≥6 PNI was identified as an independent predictor of worse OS <em>vs.</em> <6 PNI + patients (29 <em>vs.</em> 11 months, <em>p</em> < 0.001) and <6 PNI+ and PNI- patients (43 <em>vs.</em> 11 months, <em>p</em> < 0.001). PNI ≥6 was an independent negative prognostic factor of DFS <em>vs</em>. <6 PNI+ and PNI- patients (13 <em>vs</em>. 6 months, <em>p</em> = 0.022).</p></div><div><h3>Conclusions</h3><p>We report a PNI scoring system that stratifies surgically-treated PDAC patients in a graded manner that correlates with patient prognosis better than the current dichotomous (presence/absence) definition. 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Perineural invasion score system and clinical outcomes in resected pancreatic cancer patients
Background/objectives
Perineural invasion (PNI), classified according to its presence or absence in tumor specimens, is recognized as a poor prognostic factor in pancreatic ductal adenocarcinoma (PDAC) patients. Herein, we identified five histological features of PNI and investigated their impact on survival outcomes of PDAC resected patients.
Methods
Five histopathological features of PNI (diameter, number, site, sheath involvement, and mitotic figures within perineural invasion) were combined in an additional final score (ranging from 0 to 8), and clinical data of PDAC patients were retrospectively analyzed. PNI + patients were stratified in two categories according to the median score value (<6 and ≥ 6, respectively). Impact of PNI on disease-free survival (DFS) and overall survival (OS) were analyzed.
Results
Forty-five patients were enrolled, of whom 34 with PNI (PNI+) and 11 without PNI (PNI-). The DFS was 11 months vs. not reached (NR) (p = 0.258), while the OS was 19 months vs. NR (p = 0.040) in PNI+ and PNI- patients, respectively. A ≥6 PNI was identified as an independent predictor of worse OS vs. <6 PNI + patients (29 vs. 11 months, p < 0.001) and <6 PNI+ and PNI- patients (43 vs. 11 months, p < 0.001). PNI ≥6 was an independent negative prognostic factor of DFS vs. <6 PNI+ and PNI- patients (13 vs. 6 months, p = 0.022).
Conclusions
We report a PNI scoring system that stratifies surgically-treated PDAC patients in a graded manner that correlates with patient prognosis better than the current dichotomous (presence/absence) definition. However, further and larger studies are needed to support this PNI scoring system.
期刊介绍：
Pancreatology is the official journal of the International Association of Pancreatology (IAP), the European Pancreatic Club (EPC) and several national societies and study groups around the world. Dedicated to the understanding and treatment of exocrine as well as endocrine pancreatic disease, this multidisciplinary periodical publishes original basic, translational and clinical pancreatic research from a range of fields including gastroenterology, oncology, surgery, pharmacology, cellular and molecular biology as well as endocrinology, immunology and epidemiology. Readers can expect to gain new insights into pancreatic physiology and into the pathogenesis, diagnosis, therapeutic approaches and prognosis of pancreatic diseases. The journal features original articles, case reports, consensus guidelines and topical, cutting edge reviews, thus representing a source of valuable, novel information for clinical and basic researchers alike.
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