追踪一碳代谢在癌症及其他疾病中的不同路径

IF 7.8 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Cold Spring Harbor perspectives in medicine Pub Date : 2024-03-19 DOI:10.1101/cshperspect.a041533
Esther W. Lim, Christian M. Metallo
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引用次数: 0

摘要

一碳(1C)代谢是一个分布于细胞器的生化反应网络,它提供叶酸激活的 1C 单位,以支持大分子合成、甲基化和还原平衡。在高度增殖的癌细胞中,通过这些途径的通量会上调,而针对 1C 途径中的酶的抗叶酸盐长期以来一直被用于治疗癌症。在这项工作中,我们回顾了 1C 代谢的基本方面,并将其与其他生物合成和氧化还原途径联系起来,这样,1C 代谢就成了跨区的桥梁。我们进一步讨论了稳定同位素追踪技术与质谱分析相结合对研究 1C 代谢的重要性,最后强调了可利用癌细胞对 1C 代谢依赖性的治疗方法。
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Tracing the Diverse Paths of One-Carbon Metabolism in Cancer and Beyond
One-carbon (1C) metabolism is a network of biochemical reactions distributed across organelles that delivers folate-activated 1C units to support macromolecule synthesis, methylation, and reductive homeostasis. Fluxes through these pathways are up-regulated in highly proliferative cancer cells, and anti-folates, which target enzymes within the 1C pathway, have long been used in the treatment of cancer. In this work, we review fundamental aspects of 1C metabolism and place it in context with other biosynthetic and redox pathways, such that 1C metabolism acts to bridge pathways across compartments. We further discuss the importance of stable-isotope-tracing techniques combined with mass spectrometry analysis to study 1C metabolism and conclude by highlighting therapeutic approaches that could exploit cancer cells’ dependency on 1C metabolism.
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来源期刊
Cold Spring Harbor perspectives in medicine
Cold Spring Harbor perspectives in medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
14.30
自引率
1.90%
发文量
44
审稿时长
4-8 weeks
期刊介绍: Cold Spring Harbor Perspectives in Medicine is a monthly online publication comprising reviews on different aspects of a variety of diseases, covering everything from the molecular and cellular bases of disease to translational medicine and new therapeutic strategies. Cold Spring Harbor Perspectives in Medicine is thus unmatched in its depth of coverage and represents an essential source where readers can find informed surveys and critical discussion of advances in molecular medicine.
期刊最新文献
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