贵金属聚丙烯酸酯对肿瘤细胞的细胞毒性作用机制

IF 4.033 Q4 Biochemistry, Genetics and Molecular Biology Biophysics Pub Date : 2024-03-18 DOI:10.1134/S0006350923060040

A. K. Chigasova, L. A. Ostrovskaya, D. B. Korman, N. V. Bluhterova

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引用次数: 0

摘要

摘要对含金（aurumacryl）和含银（argacryl）的聚丙烯酸酯对人类肿瘤细胞（MCF-7 细胞培养物）的细胞毒活性和作用机制进行了比较研究。结果表明，这些药物具有很强的细胞毒性。发现 Argacryl 的效果是 aurumacryl 的 20 倍。研究发现，凋亡是曙红和精蒽酚诱导肿瘤细胞死亡的主要机制。发现药物对肿瘤细胞 DNA 结构的影响存在差异。

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The Mechanism of the Cytotoxic Effect of Noble Metal Polyacrylates on Tumor Cells

A comparative study of the cytotoxic activity and mechanism of action of polyacrylates containing gold (aurumacryl) and silver (argacryl) against human tumor cells (MCF-7 cell culture) has been carried out. The high cytotoxic activity of the drugs has been shown. Argacryl was found to be 20 times more effective than aurumacryl. It was found that apoptosis was the dominant mechanism in the death of tumor cells induced by aurumacryl and argacryl. Differences in the effect of drugs on the DNA structure of tumor cells were revealed.

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来源期刊

Biophysics Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.