新型图像引导经皮肺组织切除装置,集成了血管和气道密封功能:体内临床前研究。

Jorge E Salazar, Richard Fischel, Kenneth M Bueche, Kian Samra, Laura Gonzalez, Joanna C Nathan, Carolyne Lu, Joanna Rodriguez, Steven Nguyen, William E Cohn, Edward Boyle
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引用次数: 0

摘要

研究目的本研究评估了微创靶向切除术(MiTR)设备的疗效,该设备是一种新型电外科器械,可对肺部异常进行靶向切除,同时使用双极射频(RF)能量封闭血管和气道:在 7 个急性和 2 个慢性猪(7 天)模型中对 MiTR 系统进行了评估,以评价组织切除、双极射频封闭血管和气道以及在切除组织腔内应用自体血补片的效果。所有评估均记录了漏气情况。该研究获得了机构伦理委员会的批准:共切除了 19 个长 2.5 厘米、直径 1.2 厘米的肺组织样本。在 9 只动物中,有 8 只(89%)在手术完成时通过肉眼观察到止血和停气。在 2 只慢性动物中,有 2 只(100%)在 7 天的观察期内持续存在止血和气化现象。切除样本的组织学检查显示,核心实质结构得以保留,样本没有明显的组织损伤,不会影响病理分析:结论:使用 MiTR 系统经皮切除目标肺组织,在获得组织学完整样本的同时,还实现了止血和止肺。在获得监管部门批准后,使用该设备可提供比经胸针活检或支气管镜检查更多的组织供分析,并可作为视频辅助胸腔手术或开胸手术的微创替代方案。这还可以扩大病人和医生早期诊断和治疗肺癌的选择范围。
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Novel Image-Guided Percutaneous Lung Tissue Excision Device With Integrated Sealing of Blood Vessels and Airways: An In Vivo Preclinical Study.

Objective: This study evaluated the efficacy of the Minimally Invasive Targeted Resection (MiTR) device, a novel electrosurgical instrument that allows for targeted excision of a lung abnormality while using bipolar radiofrequency (RF) energy to seal blood vessels and airways.

Methods: The MiTR system was evaluated in 7 acute and 2 chronic porcine (7-day) models to evaluate the efficacy of tissue excision with bipolar RF sealing of blood vessels and airways and application of an autologous blood patch into the excised tissue cavity. Air leak was recorded for all evaluations. The study was approved by the institutional ethical board.

Results: Nineteen lung tissue samples, measuring 2.5 cm long × 1.2 cm diameter, were excised. In 8 of 9 animals (89%), hemostasis and pneumostasis were observed visually at the completion of the procedure. In 2 of 2 chronic animals (100%), hemostasis and pneumostasis persisted for the 7-day observation period. Histologic examination of the excised samples showed preservation of the core parenchymal architecture without evident tissue damage of the samples that would impair pathologic analysis.

Conclusions: Percutaneous resection of targeted lung tissue with the MiTR system demonstrated hemostasis and pneumostasis while obtaining a histologically intact sample. After regulatory approval, the use of this device could offer more tissue for analysis than a transthoracic needle biopsy or bronchoscopy and a far less invasive alternative to video-assisted thoracic surgery or thoracotomy. This may also expand patient and physician options for the early diagnosis and treatment of lung cancer.

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来源期刊
CiteScore
2.00
自引率
6.70%
发文量
80
期刊介绍: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery is the first journal whose main mission is to disseminate information specifically about advances in technology and techniques that lead to less invasive treatment of cardiothoracic and vascular disease. It delivers cutting edge original research, reviews, essays, case reports, and editorials from the pioneers and experts in the field of minimally invasive cardiothoracic and vascular disease, including biomedical engineers. Also included are papers presented at the annual ISMICS meeting. Official Journal of the International Society for Minimally Invasive Cardiothoracic Surgery
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