Renato Nisihara, Gabriela Vithoft, Isabela Alencar, Thiago Alberto F G Dos Santos, Thelma Larocca Skare
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引用次数: 0
摘要
背景:在系统性红斑狼疮(SLE)患者中发现了抗中性粒细胞胞浆抗体(ANCA)。在这项研究中,我们调查了巴西系统性红斑狼疮患者样本中是否存在 ANCA 及其与临床和血清学结果之间可能存在的关联。此外,我们还回顾了有关系统性红斑狼疮 ANCA 的文献:使用间接免疫荧光法(IIF)检测了 130 名患者体内是否存在 ANCA。29.9%的病例检测结果呈阳性(17.6%为pANCA,11.5%为cANCA)。cANCA 与狼疮抗凝物相关,pANCA 与外周血管炎呈阳性,而与抗 SSB/La 抗体呈阴性。在纳入文献综述的 22 项研究中,ANCA 阳性率的范围很广(IIF 为 13% 至 81.1%,ELISA 为 0 至 22.2%)。在亚洲人群中,ANCA 与肾损伤有关。尽管在个别研究中也发现了其他关联,但并未得到一致报道:在巴西样本中发现的 ANCA 患病率在文献报道的范围内,这些自身抗体在男性和血管炎患者中更为常见。文献显示,ANCA与系统性红斑狼疮疾病活动性或临床特征之间的关系存在争议。
ANCA in patients with systemic lupus erythematosus. A cross sectional study in Brazilian patients and review of literature.
Background: Antineutrophil cytoplasmatic antibodies (ANCA) have been detected in patients with systemic lupus erythematosus (SLE). In this study, we investigated the presence of ANCA in a sample of Brazilian SLE patients and its possible associations with clinical and serological outcomes. Additionally, we reviewed the literature of on ANCA in SLE.
Results: The presence of ANCA was detected in 130 patients using indirect immunofluorescence (IIF). The test was positive in 29.9% of the cases (17.6% pANCA and 11.5% cANCA). Male sex and peripheral vasculitis were more prevalent in the ANCA-positive sample. cANCA was associated with lupus anticoagulant and pANCA had a positive association with peripheral vasculitis and a negative association with anti- SSB/La antibodies. In the 22 studies included in the literature review, a wide range of ANCA positivity was found (13% to 81.1% by IIF and 0 to 22.2% by ELISA). ANCA was associated with renal damage in the Asian population. Although other associations have been found in isolated studies, they were not consistently reported.
Conclusions: The ANCA prevalence found in this Brazilian sample was within the range reported in the literature and these autoantibodies were more frequent in males and in patients with vasculitis. The literature showed controversial results on the association between ANCA and SLE disease activity or clinical characteristics.
期刊介绍:
The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…