J. Manuel Matiz-González, Jesús A. Ballesteros-Ballesteros, María Hernández, Julián A. Mejorano-Fonseca, Claudia Cuervo, Álvaro A. Faccini-Martínez, Marylin Hidalgo, Jairo Pérez-Torres, Carlos Ramiro Silva-Ramos
{"title":"全球蝙蝠寄生的 P1/致病性钩端螺旋体物种的遗传多样性。","authors":"J. Manuel Matiz-González, Jesús A. Ballesteros-Ballesteros, María Hernández, Julián A. Mejorano-Fonseca, Claudia Cuervo, Álvaro A. Faccini-Martínez, Marylin Hidalgo, Jairo Pérez-Torres, Carlos Ramiro Silva-Ramos","doi":"10.1111/zph.13126","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Introduction</h3>\n \n <p>Bats are a diverse group of mammals that have unique features allowing them to act as reservoir hosts for several zoonotic pathogens such as <i>Leptospira</i>. Leptospires have been classified into pathogenic, intermediate, and saprophytic groups and more recently into clades P1, P2, S1, and S2, being all the most important pathogenic species related to leptospirosis included within the P1/pathogenic clade. <i>Leptospira</i> has been detected from bats in several regions worldwide; however, the diversity of leptospires harboured by bats is still unknown.</p>\n </section>\n \n <section>\n \n <h3> Aim</h3>\n \n <p>The aim of the present study was to determine the genetic diversity of <i>Leptospira</i> spp. harboured by bats worldwide.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A systematic review was conducted on four databases to retrieve studies in which <i>Leptospira</i> was detected from bats. All studies were screened to retrieve all available <i>Leptospira</i> spp. 16S rRNA sequences from the GenBank database and data regarding their origin. Sequences obtained were compared with each other and reference sequences of <i>Leptospira</i> species and analysed through phylogenetic analysis.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>A total of 418 <i>Leptospira</i> spp. 16S rRNA sequences isolated from 55 bat species from 14 countries were retrieved from 15 selected manuscripts. From these, 417 sequences clustered within the P1/pathogenic group, and only one sequence clustered within the P2/intermediate group. Six major clades of P1/pathogenic <i>Leptospira</i> spp. were identified, three of them composed exclusively of sequences obtained from bats.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>We identified that bats harbour a great genetic diversity of <i>Leptospira</i> spp. that form part of the P1/pathogenic clade, some of which are closely related to leptospirosis-associated species. This finding contributes to the knowledge of the diversity of leptospires hosted by bats worldwide and reinforces the role of bats as reservoirs of P1/pathogenic <i>Leptospira</i> spp.</p>\n </section>\n </div>","PeriodicalId":24025,"journal":{"name":"Zoonoses and Public Health","volume":"71 5","pages":"457-468"},"PeriodicalIF":2.4000,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Genetic diversity of P1/pathogenic Leptospira species hosted by bats worldwide\",\"authors\":\"J. Manuel Matiz-González, Jesús A. Ballesteros-Ballesteros, María Hernández, Julián A. Mejorano-Fonseca, Claudia Cuervo, Álvaro A. Faccini-Martínez, Marylin Hidalgo, Jairo Pérez-Torres, Carlos Ramiro Silva-Ramos\",\"doi\":\"10.1111/zph.13126\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Introduction</h3>\\n \\n <p>Bats are a diverse group of mammals that have unique features allowing them to act as reservoir hosts for several zoonotic pathogens such as <i>Leptospira</i>. Leptospires have been classified into pathogenic, intermediate, and saprophytic groups and more recently into clades P1, P2, S1, and S2, being all the most important pathogenic species related to leptospirosis included within the P1/pathogenic clade. <i>Leptospira</i> has been detected from bats in several regions worldwide; however, the diversity of leptospires harboured by bats is still unknown.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Aim</h3>\\n \\n <p>The aim of the present study was to determine the genetic diversity of <i>Leptospira</i> spp. harboured by bats worldwide.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>A systematic review was conducted on four databases to retrieve studies in which <i>Leptospira</i> was detected from bats. All studies were screened to retrieve all available <i>Leptospira</i> spp. 16S rRNA sequences from the GenBank database and data regarding their origin. Sequences obtained were compared with each other and reference sequences of <i>Leptospira</i> species and analysed through phylogenetic analysis.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>A total of 418 <i>Leptospira</i> spp. 16S rRNA sequences isolated from 55 bat species from 14 countries were retrieved from 15 selected manuscripts. From these, 417 sequences clustered within the P1/pathogenic group, and only one sequence clustered within the P2/intermediate group. Six major clades of P1/pathogenic <i>Leptospira</i> spp. were identified, three of them composed exclusively of sequences obtained from bats.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>We identified that bats harbour a great genetic diversity of <i>Leptospira</i> spp. that form part of the P1/pathogenic clade, some of which are closely related to leptospirosis-associated species. This finding contributes to the knowledge of the diversity of leptospires hosted by bats worldwide and reinforces the role of bats as reservoirs of P1/pathogenic <i>Leptospira</i> spp.</p>\\n </section>\\n </div>\",\"PeriodicalId\":24025,\"journal\":{\"name\":\"Zoonoses and Public Health\",\"volume\":\"71 5\",\"pages\":\"457-468\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2024-03-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zoonoses and Public Health\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/zph.13126\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zoonoses and Public Health","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/zph.13126","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Genetic diversity of P1/pathogenic Leptospira species hosted by bats worldwide
Introduction
Bats are a diverse group of mammals that have unique features allowing them to act as reservoir hosts for several zoonotic pathogens such as Leptospira. Leptospires have been classified into pathogenic, intermediate, and saprophytic groups and more recently into clades P1, P2, S1, and S2, being all the most important pathogenic species related to leptospirosis included within the P1/pathogenic clade. Leptospira has been detected from bats in several regions worldwide; however, the diversity of leptospires harboured by bats is still unknown.
Aim
The aim of the present study was to determine the genetic diversity of Leptospira spp. harboured by bats worldwide.
Methods
A systematic review was conducted on four databases to retrieve studies in which Leptospira was detected from bats. All studies were screened to retrieve all available Leptospira spp. 16S rRNA sequences from the GenBank database and data regarding their origin. Sequences obtained were compared with each other and reference sequences of Leptospira species and analysed through phylogenetic analysis.
Results
A total of 418 Leptospira spp. 16S rRNA sequences isolated from 55 bat species from 14 countries were retrieved from 15 selected manuscripts. From these, 417 sequences clustered within the P1/pathogenic group, and only one sequence clustered within the P2/intermediate group. Six major clades of P1/pathogenic Leptospira spp. were identified, three of them composed exclusively of sequences obtained from bats.
Conclusion
We identified that bats harbour a great genetic diversity of Leptospira spp. that form part of the P1/pathogenic clade, some of which are closely related to leptospirosis-associated species. This finding contributes to the knowledge of the diversity of leptospires hosted by bats worldwide and reinforces the role of bats as reservoirs of P1/pathogenic Leptospira spp.
期刊介绍：
Zoonoses and Public Health brings together veterinary and human health researchers and policy-makers by providing a venue for publishing integrated and global approaches to zoonoses and public health. The Editors will consider papers that focus on timely collaborative and multi-disciplinary research in zoonoses and public health. This journal provides rapid publication of original papers, reviews, and potential discussion papers embracing this collaborative spirit. Papers should advance the scientific knowledge of the sources, transmission, prevention and control of zoonoses and be authored by scientists with expertise in areas such as microbiology, virology, parasitology and epidemiology. Articles that incorporate recent data into new methods, applications, or approaches (e.g. statistical modeling) which enhance public health are strongly encouraged.
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