释放潜能：电子传递链在免疫代谢中的作用。

IF 13.1 1区医学 Q1 IMMUNOLOGY Trends in Immunology Pub Date : 2024-04-01 Epub Date: 2024-03-18 DOI:10.1016/j.it.2024.02.002

Alessia Zotta, Luke A J O'Neill, Maureen Yin

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引用次数: 0

摘要

电子传递链（ETC）将电子传递与质子泵结合起来以产生 ATP，它还能调节特定的先天性和适应性免疫细胞功能。虽然 NLRP3 炎症小体的激活最初与复合体 I 和 III 产生的活性氧（ROS）有关，但最近的研究表明，需要有一个完整的 ETC 为 ATP 提供燃料。复合体 II 可能负责 Th1 细胞的增殖，在某些情况下还负责效应细胞因子的产生。调节性 T（Treg）细胞的功能需要复合体 III，而氧化磷酸化（OXPHOS）和复合体 I、IV 和 V 可维持 B 淋巴细胞的增殖和抗体生成，B 调节性（Breg）细胞的功能也需要 OXPHOS。尽管存在挑战，但 ETC 显示出了针对免疫相关疾病和免疫肿瘤学的治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Unlocking potential: the role of the electron transport chain in immunometabolism.

The electron transport chain (ETC) couples electron transfer with proton pumping to generate ATP and it also regulates particular innate and adaptive immune cell function. While NLRP3 inflammasome activation was initially linked to reactive oxygen species (ROS) produced from Complexes I and III, recent research suggests that an intact ETC fueling ATP is needed. Complex II may be responsible for Th1 cell proliferation and in some cases, effector cytokine production. Complex III is required for regulatory T (Treg) cell function, while oxidative phosphorylation (OXPHOS) and Complexes I, IV, and V sustain proliferation and antibody production in B lymphocytes, with OXPHOS also being required for B regulatory (Breg) cell function. Despite challenges, the ETC shows therapeutic targeting potential for immune-related diseases and in immuno-oncology.

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来源期刊

Trends in Immunology 医学-免疫学

CiteScore

25.10

自引率

0.60%

发文量

130

审稿时长

6-12 weeks

期刊介绍： Trends in Immunology serves as a vital platform for tracking advancements across various areas of immunology, offering concise reviews and hypothesis-driven viewpoints in each issue. With additional sections providing comprehensive coverage, the journal offers a holistic view of immunology. This broad perspective makes it an invaluable resource for researchers, educators, and students, facilitating the connection between basic and clinical immunology. Recognized as one of the top monthly review journals in its field, Trends in Immunology is highly regarded by the scientific community.

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