褪黑素的事实：褪黑素在分子和细胞水平上缺乏促进免疫炎症的能力。

IF 3.3 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochimie Pub Date : 2024-03-18 DOI:10.1016/j.biochi.2024.03.010

Jean A. Boutin , Valérie Hamon de Almeida , Nathalie Coussay , Céline Legros , Gilles Ferry , Karine Reybier

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引用次数: 0

摘要

据称，褪黑素具有的特性之一是免疫炎症诱导能力，据报道，褪黑素在大多数人类病理情况下都具有一些重要的作用。在本文中，我们测量了褪黑激素对已建立的免疫炎症细胞模型的影响，但没有发现任何影响。本文对这些差异进行了讨论，特别是因为这些特性是在药理浓度（1 μM及以上）下报告的，在此浓度下褪黑素受体会因内化而脱敏，从而导致推测的非受体依赖性作用机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Melatonin facts: Melatonin lacks immuno-inflammation boosting capacities at the molecular and cellular levels

Among the properties melatonin is claimed to possess, are the immuno-inflammation inductive capacities that would be responsible of some of the paramount of activities melatonin is reported to have in most of the human pathological conditions. In the present paper, we measured the effect of melatonin on established cellular models of immuno-inflammation, and found none. The discrepancies are discussed, especially because those properties are reported at pharmacological concentration (1 μM and beyond) at which the melatonin receptors are desensitized by internalization, leading to putative non-receptor-dependent mechanism of action.

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来源期刊

Biochimie 生物-生化与分子生物学

CiteScore

7.20

自引率

2.60%

发文量

219

审稿时长

40 days

期刊介绍： Biochimie publishes original research articles, short communications, review articles, graphical reviews, mini-reviews, and hypotheses in the broad areas of biology, including biochemistry, enzymology, molecular and cell biology, metabolic regulation, genetics, immunology, microbiology, structural biology, genomics, proteomics, and molecular mechanisms of disease. Biochimie publishes exclusively in English. Articles are subject to peer review, and must satisfy the requirements of originality, high scientific integrity and general interest to a broad range of readers. Submissions that are judged to be of sound scientific and technical quality but do not fully satisfy the requirements for publication in Biochimie may benefit from a transfer service to a more suitable journal within the same subject area.