补充和替代医学对败血症后认知缺陷和神经炎症的影响。

L I Zhenxuan, Wang Xuerui, Luis Ulloa, Ayman Youssef, Bai Yunjing, X U Xiaolong, Liu Qingquan
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引用次数: 0

摘要

脓毒症相关脑病(SAE)是脓毒症的一种常见表现,其范围从轻微的意识模糊和谵妄到严重的认知障碍和深度昏迷。SAE 与较高的死亡率和长期预后相关,尤其是认知功能的显著下降。SAE 的发病机制可能包括由全身炎症和大脑缺血性病变、血脑屏障破坏、氧化应激、神经递质功能障碍和严重的小胶质细胞活化介导的神经炎症。越来越多的证据表明,补充和替代医学,尤其是中医(TCM),有利于缓解脓毒症后的认知能力下降。在此,我们总结了近几十年来传统中草药、中药配方和针灸疗法在败血症后神经功能障碍动物模型中的研究,并回顾了其潜在机制。
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Complementary and alternative medicine on cognitive defects and neuroinflammation after sepsis.

Sepsis-associated encephalopathy (SAE) is a common manifestation of sepsis, ranging from mild confusion and delirium to severe cognitive impairment and deep coma. SAE is associated with higher mortality and long-term outcomes, particularly substantial declines in cognitive function. The mechanisms of SAE probably include neuroinflammation that is mediated by systemic inflammation and ischemic lesions in the brain, a disrupted blood-brain barrier, oxidative stress, neurotransmitter dysfunction, and severe microglial activation. Increasing evidence suggests that complementary and alternative medicine, especially Traditional Chinese Medicine (TCM), is favorable in alleviating cognitive decline after sepsis. Here, we summarized the studies of traditional herbal remedies, TCM formulas and acupuncture therapy in animal models of neurological dysfunctions after sepsis in recent decades and reviewed their potential mechanisms.

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