慢性阻塞性肺病和合并症中的肌肉骨骼串扰:新的作用和治疗潜力。

IF 12 1区 医学 Q1 PHARMACOLOGY & PHARMACY Pharmacology & Therapeutics Pub Date : 2024-03-18 DOI:10.1016/j.pharmthera.2024.108635
Kevin Mou, Stanley M.H. Chan, Ross Vlahos
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引用次数: 0

摘要

慢性阻塞性肺病(COPD)是一种多发性呼吸系统疾病,其特点是进行性气流受限和全身性影响。越来越明显的是,慢性阻塞性肺病对呼吸系统的影响远远超出了呼吸系统,而是扩展到了多个器官系统。其中,肌肉骨骼系统在慢性阻塞性肺病及其相关并发症的发病机制和治疗中发挥着核心作用。肌肉功能障碍和骨质疏松症是慢性阻塞性肺病患者常见的肌肉骨骼疾病,会导致运动能力和整体健康水平大幅下降。这些表现受到全身炎症、氧化应激和激素失衡的影响,而这些都是慢性阻塞性肺病的特征。最近的研究发现,慢性阻塞性肺病和肌肉骨骼合并症之间存在着错综复杂的相互作用,这表明肌肉和骨骼组织可能会通过释放信号分子(即 "肌动素 "和 "骨动素")进行交叉交流。我们探讨了这种动态关系,尤其关注免疫系统在慢性阻塞性肺病患者肌肉和骨骼之间的交叉交流中的作用。此外,我们还深入研究了治疗慢性阻塞性肺病肌肉骨骼疾病的现有和新兴治疗策略。它强调了针对慢性阻塞性肺病的呼吸和肌肉骨骼两方面的个性化治疗方法的发展,为与这种复杂病症作斗争的患者带来了改善生活质量的希望。本综述强调了认识慢性阻塞性肺病对肌肉骨骼系统及其并发症的深远影响的重要性。通过揭示这些系统之间错综复杂的联系并探索创新的治疗途径,我们可望提高慢性阻塞性肺病患者的整体护理水平和治疗效果,最终为改善患者的健康和福祉带来希望。
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Musculoskeletal crosstalk in chronic obstructive pulmonary disease and comorbidities: Emerging roles and therapeutic potentials

Chronic Obstructive Pulmonary Disease (COPD) is a multifaceted respiratory disorder characterized by progressive airflow limitation and systemic implications. It has become increasingly apparent that COPD exerts its influence far beyond the respiratory system, extending its impact to various organ systems. Among these, the musculoskeletal system emerges as a central player in both the pathogenesis and management of COPD and its associated comorbidities. Muscle dysfunction and osteoporosis are prevalent musculoskeletal disorders in COPD patients, leading to a substantial decline in exercise capacity and overall health. These manifestations are influenced by systemic inflammation, oxidative stress, and hormonal imbalances, all hallmarks of COPD. Recent research has uncovered an intricate interplay between COPD and musculoskeletal comorbidities, suggesting that muscle and bone tissues may cross-communicate through the release of signalling molecules, known as “myokines” and “osteokines”. We explored this dynamic relationship, with a particular focus on the role of the immune system in mediating the cross-communication between muscle and bone in COPD. Moreover, we delved into existing and emerging therapeutic strategies for managing musculoskeletal disorders in COPD. It underscores the development of personalized treatment approaches that target both the respiratory and musculoskeletal aspects of COPD, offering the promise of improved well-being and quality of life for individuals grappling with this complex condition. This comprehensive review underscores the significance of recognizing the profound impact of COPD on the musculoskeletal system and its comorbidities. By unravelling the intricate connections between these systems and exploring innovative treatment avenues, we can aspire to enhance the overall care and outcomes for COPD patients, ultimately offering hope for improved health and well-being.

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来源期刊
CiteScore
23.00
自引率
0.70%
发文量
222
审稿时长
90 days
期刊介绍: Pharmacology & Therapeutics, in its 20th year, delivers lucid, critical, and authoritative reviews on current pharmacological topics.Articles, commissioned by the editor, follow specific author instructions.This journal maintains its scientific excellence and ranks among the top 10 most cited journals in pharmacology.
期刊最新文献
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