加纳 2 型糖尿病患者踝肱指数低与相位角有关

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-03-16 DOI:10.1016/j.deman.2024.100216

Jennifer Adjepong Agyekum , Kwame Yeboah

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引用次数: 0

摘要

背景2型糖尿病（T2DM）与动脉粥样硬化性大血管疾病的高负担相关，而动脉粥样硬化性大血管疾病可通过踝肱指数（ABI）进行诊断。生物电阻抗分析得出的相位角（PhA）与心血管疾病的发展有关。我们调查了加纳 T2DM 患者低 ABI 与相位角之间的关系。使用 8 赫兹连续多普勒测量 ABI，ABI≤0.9 为低 ABI。从生物电阻抗分析的电阻和电抗中获得 PhA。与正常 ABI 患者相比，低 ABI T2DM 患者的 PhA 值降低（7.5 ± 1.9 vs 8.3 ± 2.2 单位，p = 0.004）。在未调整模型[OR (95 % CI) = 0.79 (0.48 - 0.95)，p = 0.007]和调整模型[0.88 (0.43 - 0.98)，p = 0.036]中，相位角增加 1°与低 ABI 的几率降低有关。此外，与正常 ABI 患者相比，低 ABI 患者的 PhA 值较低。

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Phase angle associated is with low ankle-brachial index in type 2 diabetes patients in Ghana

Background

Type 2 diabetes (T2DM) is associated with high burden of atherosclerotic macrovascular disease which could be diagnosed with ankle-brachial index (ABI). Phase angle (PhA) from bioelectric impedance analysis is associated with the development of cardiovascular diseases. We investigated the association between low ABI and phase angle in T2DM patients in Ghana.

Method

In a cross-sectional study, 462 T2DM patients were systematically recruited for the study. ABI was measured using an 8 Hz continuous Doppler and ABI≤0.9 was considered to be low ABI. PhA was obtained from resistance and reactance from Bioelectric impedance analysis.

Results

The prevalence of low ABI was 16 % in the study population. T2DM patients with low ABI have decreased PhA (7.5 ± 1.9 vs 8.3 ± 2.2 units, p = 0.004) compared to those with normal ABI. An increase in phase angle by 1° was associated with a decrease in odds of having low ABI in unadjusted [OR (95 % CI) = 0.79 (0.48 – 0.95), p = 0.007] and adjusted models [0.88 (0.43 – 0.98), p = 0.036].

Conclusion

The prevalence of low ABI in T2DM patients in this study was 16 %. Also, PhA was lower in patients with low ABI compared to those with normal ABI.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.