分析登革热流行病模型单延迟微分方程的动力学和稳定性

A. Venkatesh , M. Prakash Raj , B. Baranidharan
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引用次数: 0

摘要

本文介绍了一种模拟登革热病毒随时间在人群中传播的数学模型。该模型考虑到了传播延迟、抑制效应的影响、免疫力丧失和部分免疫力的存在等方面。该模型已经过验证,以确保其正向性和有界性。利用先进的新一代矩阵方法推导出了模型的基本繁殖数 R0。对模型的稳定性标准进行了分析,并研究了平衡点。结果表明,在适当的情况下,当存在延迟时,无病毒均衡点和流行均衡点都具有局部稳定性。利用适当的 Lyapunov 函数分析了平衡点的全局渐进稳定性。此外,模型还出现了反向分叉,即无病毒均衡与稳定的地方病均衡并存。通过使用敏感性分析技术,研究表明某些因素对模型的行为有重大影响。研究通过数字实例和模拟验证了理论概念,从而巧妙地阐明了研究结果的影响。此外,我们的研究还发现,提高对受感染病媒和人群的抑制率会导致平衡点降低,这表明存在流行状态。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Analyzing dynamics and stability of single delay differential equations for the dengue epidemic model

This paper introduces a mathematical model that simulates the transmission of the dengue virus in a population over time. The model takes into account aspects such as delays in transmission, the impact of inhibitory effects, the loss of immunity, and the presence of partial immunity. The model has been verified to ensure the positivity and boundedness. The basic reproduction number R0 of the model is derived using the advanced next-generation matrix approach. An analysis is conducted on the stability criteria of the model, and equilibrium points are investigated. Under appropriate circumstances, it was shown that there is local stability in both the virus-free equilibrium and the endemic equilibrium points when there is a delay. Analyzing the global asymptotic stability of equilibrium points is done by using the appropriate Lyapunov function. In addition, the model exhibits a backward bifurcation, in which the virus-free equilibrium coexists with a stable endemic equilibrium. By using a sensitivity analysis technique, it has been shown that some factors have a substantial influence on the behavior of the model. The research adeptly elucidates the ramifications of its results by effortlessly validating theoretical concepts with numerical examples and simulations. Furthermore, our research revealed that augmenting the rate of inhibition on infected vectors and people leads to a reduction in the equilibrium point, suggesting the presence of an endemic state.

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来源期刊
Results in Control and Optimization
Results in Control and Optimization Mathematics-Control and Optimization
CiteScore
3.00
自引率
0.00%
发文量
51
审稿时长
91 days
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