设计和评估基于肽的癌症疫苗的合成给药配方。

IF 5 Q1 ENGINEERING, BIOMEDICAL BME frontiers Pub Date : 2024-03-21 eCollection Date: 2024-01-01 DOI:10.34133/bmef.0038
Kefan Song, Suzie H Pun
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引用次数: 0

摘要

随着新抗原鉴定的最新进展,基于多肽的癌症疫苗在免疫疗法领域具有巨大的潜力。然而,快速清除、低免疫原性和抗原呈递细胞(APC)摄取不足限制了多肽类癌症疫苗的疗效。本综述探讨了阻碍疫苗效率的障碍,重点介绍了合成递送系统的最新进展,并介绍了淋巴结引流、抗原呈递细胞递送、交叉呈递策略和佐剂结合等关键递送步骤的策略。本文还讨论了评估疫苗效率的临床前研究设计,包括疫苗给药途径和小鼠肿瘤模型。
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Design and Evaluation of Synthetic Delivery Formulations for Peptide-Based Cancer Vaccines.

With the recent advances in neoantigen identification, peptide-based cancer vaccines offer substantial potential in the field of immunotherapy. However, rapid clearance, low immunogenicity, and insufficient antigen-presenting cell (APC) uptake limit the efficacy of peptide-based cancer vaccines. This review explores the barriers hindering vaccine efficiency, highlights recent advancements in synthetic delivery systems, and features strategies for the key delivery steps of lymph node (LN) drainage, APC delivery, cross-presentation strategies, and adjuvant incorporation. This paper also discusses the design of preclinical studies evaluating vaccine efficiency, including vaccine administration routes and murine tumor models.

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CiteScore
7.10
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审稿时长
16 weeks
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