Hui Xiao*, Yanyue Feng*, William R. F. Goundry and Staffan Karlsson,
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引用次数: 0
摘要
使用有机溶剂进行分离和提纯是制药过程中不可或缺的程序。然而，它们仍然严重依赖蒸馏和色谱等传统分离技术，导致高能耗和大量溶剂消耗。作为一种替代方法，有机溶剂纳滤（OSN）具有能耗低、固体废物产生量少、易于放大和融入连续工艺等优点。因此，在制药领域采用膜技术来提高工艺可持续性和能源效率的兴趣日益浓厚。本综述全面总结了有机溶剂纳滤的最新进展（尤其是过去 10 年）及其在制药行业的应用，包括活性药物成分的浓缩和纯化、均相催化剂回收、溶剂交换和回收以及 OSN 辅助的多肽/寡核苷酸合成。此外，还详细讨论了膜技术在制药应用中的挑战和未来前景。
Organic Solvent Nanofiltration in Pharmaceutical Applications
Separation and purification in organic solvents are indispensable procedures in pharmaceutical manufacturing. However, they still heavily rely on the conventional separation technologies of distillation and chromatography, resulting in high energy and massive solvent consumption. As an alternative, organic solvent nanofiltration (OSN) offers the benefits of low energy consumption, low solid waste generation, and easy scale-up and incorporation into continuous processes. Thus, there is a growing interest in employing membrane technology in the pharmaceutical area to improve process sustainability and energy efficiency. This Review comprehensively summarizes the recent progress (especially the last 10 years) of organic solvent nanofiltration and its applications in the pharmaceutical industry, including the concentration and purification of active pharmaceutical ingredients, homogeneous catalyst recovery, solvent exchange and recovery, and OSN-assisted peptide/oligonucleotide synthesis. Furthermore, the challenges and future perspectives of membrane technology in pharmaceutical applications are discussed in detail.
期刊介绍：
The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.
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