饮用咖啡、茶和红酒对高血压患者有益吗?

IF 3.6 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Postgraduate Medical Journal Pub Date : 2024-07-18 DOI:10.1093/postmj/qgae039
Shuchen Zhang, Boyang Xiang, Xiangyu Su, Yujia Zhou, Yiheng Zhao, Xiang Zhou
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引用次数: 0

摘要

目的:研究茶、咖啡和红葡萄酒摄入量与高血压患者健康风险的关系:研究高血压患者茶、咖啡和红葡萄酒摄入量与健康风险的关系:这项前瞻性队列研究包括英国生物库队列中的高血压患者。研究暴露包括自我报告的咖啡、茶和红葡萄酒摄入量。主要结果是全因死亡率,次要结果是心血管死亡率和心血管疾病。采用 Cox 回归模型分析了饮料摄入量与结果之间的关系。结果:结果:共纳入 187 708 名高血压患者。中位随访期为 13.8 年。在高血压患者中,每天喝 1 至 2 杯咖啡或 3 至 4 杯茶与每天喝不到 1 杯咖啡相比,全因死亡风险最低[咖啡的危险比为 0.943(95% 置信区间,0.908-0.979);茶的危险比为 0.882(95% 置信区间,0.841-0.924)]。红葡萄酒摄入量与全因死亡风险成反比。剂量-反应分析表明,咖啡摄入量高(约大于或等于六杯/天)与心血管死亡和心血管疾病风险增加有显著相关性,但茶和红葡萄酒摄入量高则没有显著相关性。此外,用茶代替白开水(而不是咖啡)能显著降低全因死亡率和心血管疾病的风险。用红葡萄酒代替其他酒精饮料也能显著降低所有三种结果的风险:这些研究结果表明,茶和红葡萄酒(而非咖啡)可以作为高血压人群健康饮食的一部分。
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Is coffee, tea, and red wine consumption beneficial for individuals with hypertension?

Objective: To investigate the associations of tea, coffee, and red wine intakes with health risks among individuals with hypertension.

Methods: This prospective cohort study included participants with hypertension from the UK Biobank cohort. Study exposures included self-reported intakes of coffee, tea, and red wine. The primary outcome was all-cause mortality, and the secondary outcomes were cardiovascular mortality and cardiovascular disease. The associations of beverage intake with outcomes were analyzed using Cox regression models. The hazard ratios and 95% confidence intervals were estimated.

Results: A total of 187 708 participants with hypertension were included. The median follow-up period was 13.8 years. In individuals with hypertension, drinking one to two cups/day of coffee or three to four cups/day of tea was significantly associated with the lowest risk of all-cause mortality compared with less than one cup/day [hazard ratio for coffee, 0.943 (95% confidence interval, 0.908-0.979); hazard ratio for tea, 0.882 (95% confidence interval, 0.841-0.924)]. Red wine intake was inversely associated with all-cause mortality risk. Dose-response analysis revealed that high coffee intake (approximately greater than or equal to six cups/day) was significantly associated with increased risks of cardiovascular mortality and cardiovascular disease, but high tea and red wine intakes were not. Furthermore, replacing plain water with tea, but not coffee, significantly reduced the risks of all-cause mortality and cardiovascular disease. Replacing other alcoholic beverages with red wine also significantly reduced the risks of all three outcomes.

Conclusions: These findings suggest that tea and red wine, but not coffee, can be part of a healthy diet for the hypertensive population.

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来源期刊
Postgraduate Medical Journal
Postgraduate Medical Journal 医学-医学:内科
CiteScore
8.50
自引率
2.00%
发文量
131
审稿时长
2.5 months
期刊介绍: Postgraduate Medical Journal is a peer reviewed journal published on behalf of the Fellowship of Postgraduate Medicine. The journal aims to support junior doctors and their teachers and contribute to the continuing professional development of all doctors by publishing papers on a wide range of topics relevant to the practicing clinician and teacher. Papers published in PMJ include those that focus on core competencies; that describe current practice and new developments in all branches of medicine; that describe relevance and impact of translational research on clinical practice; that provide background relevant to examinations; and papers on medical education and medical education research. PMJ supports CPD by providing the opportunity for doctors to publish many types of articles including original clinical research; reviews; quality improvement reports; editorials, and correspondence on clinical matters.
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