意大利儿科队列中的维生素 D 状态：吸烟是否有影响？

IF 1.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM Journal of Clinical Research in Pediatric Endocrinology Pub Date : 2024-09-05 Epub Date: 2024-03-25 DOI:10.4274/jcrpe.galenos.2024.2023-11-16

Maria Grazia Clemente, Dario Argiolas, Stefania Bassu, Angela Bitti, Cristian Locci, Mauro Argiolas, Lino Argiolas, Laura Saderi, Mariangela V Puci, Giovanni Sotgiu, Mary E Blue, Roberto Antonucci

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引用次数: 0

摘要

引言维生素 D 缺乏症是全球常见的公共卫生问题。本研究旨在调查意大利撒丁岛（北纬 40°）儿童的维生素 D 状况及其潜在决定因素：共招募了 182 名儿童（男性：51.7%；年龄中位数：9 岁），为期 12 个月。血清 25（OH）D 通过免疫-化学发光测定法进行测量。调查问卷用于收集包括被动吸烟在内的其他变量信息：全组平均（标清）血清 25（OH）D 为 25.2（8.3）纳克/毫升。大多数儿童（人数=123，占67.6%）的维生素D充足值大于20纳克/毫升，而约1/3的儿童维生素D不足/缺乏值（小于20纳克/毫升，人数=59，占32.4%）。在所调查的变量中，被动吸烟与 25（OH）D 水平不足显著相关（p 结论：我们的研究结果进一步证明，维生素 D 不足在意大利儿童中很常见，并证明被动吸烟是导致维生素 D 不足的一个重要风险因素。

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Vitamin D Status in an Italian Pediatric Cohort: Is There a Role for Tobacco Smoking Exposure?

Objective: Vitamin D deficiency is a common public health issue worldwide. The purpose of this study was to investigate the vitamin D status and its potential determinants in children residing in Sardinia (40°N), Italy.

Methods: Children were enrolled over a 12-month period. Serum 25(OH)D was measured by an immunochemiluminescence assay. A questionnaire was used to gather information on other variables, including passive smoke exposure.

Results: A total of 182 children (males: 51.7%; median age: 9 years) were included. Mean±standard deviation serum 25(OH)D was 25.2±8.3 ng/mL for the whole group. The majority (n=123, 67.6%) had vitamin D sufficient values >20 ng/mL, while 32.4% (n=59) had vitamin D insufficient/deficient values (≤20 ng/mL). Among the variables investigated, passive smoke exposure was significantly associated with insufficient 25(OH)D levels (p<0.0001).

Conclusion: Our results confirm that hypovitaminosis D is common in Italian children. Furthermore, passive smoke exposure was identified as a significant risk factor for hypovitaminosis D.

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来源期刊

Journal of Clinical Research in Pediatric Endocrinology ENDOCRINOLOGY & METABOLISM-PEDIATRICS

CiteScore

3.60

自引率

5.30%

发文量

审稿时长

20 weeks

期刊介绍： The Journal of Clinical Research in Pediatric Endocrinology (JCRPE) publishes original research articles, reviews, short communications, letters, case reports and other special features related to the field of pediatric endocrinology. JCRPE is published in English by the Turkish Pediatric Endocrinology and Diabetes Society quarterly (March, June, September, December). The target audience is physicians, researchers and other healthcare professionals in all areas of pediatric endocrinology.