动物胃肠道暴露于微粒和 DNA 损伤:纳米毒理学高峰期之前、期间和之后的研究综述。

IF 6.4 2区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Mutation Research-Reviews in Mutation Research Pub Date : 2024-01-01 DOI:10.1016/j.mrrev.2024.108491
Peter Møller, Martin Roursgaard
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引用次数: 0

摘要

人类每天都会摄入微粒和纤维。非消化性碳水化合物有益健康,食品添加剂被认为是安全的。然而,二氧化钛(E171)已在欧盟被禁用,因为欧洲食品安全局不再认为它无遗传毒性。摄入微塑料和纳米塑料是一种新的接触方式;多年来,它们对人类的潜在危害一直没有引起人们的注意。在这篇综述中,我们评估了口服人造微粒/纤维与胃肠道细胞和二级组织遗传毒性之间的关联。我们共发现了 137 项有关口腔接触微粒和纤维的研究。其中包括石棉、柴油机废气颗粒、氧化钛、纳米银颗粒、氧化锌、合成无定形二氧化硅和某些其他纳米材料。在遗传毒性方面,19 项研究显示了积极的结果,25 项研究显示了无效的结果,5 篇论文显示了模棱两可的结果。最近的研究似乎显示了无效效应,而早期研究中基因毒性阳性结果的比例较高。遗传毒性效应似乎主要集中在对柴油机废气微粒和二氧化钛的研究中,而对纳米银微粒、氧化锌和合成无定形二氧化硅的研究似乎主要显示出无效效应。最广泛使用的基因毒性试验是碱性彗星试验和微核试验。使用氧化损伤 DNA、DNA 双链断裂(γH2AX 检测法)和突变的可靠测量方法进行基因毒性检测的结果相对较少。总体而言,有证据表明,动物经口接触微粒和纤维会产生遗传毒性。
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Gastrointestinal tract exposure to particles and DNA damage in animals: A review of studies before, during and after the peak of nanotoxicology

Humans ingest particles and fibers on daily basis. Non-digestible carbohydrates are beneficial to health and food additives are considered safe. However, titanium dioxide (E171) has been banned in the European Union because the European Food Safety Authority no longer considers it non-genotoxic. Ingestion of microplastics and nanoplastics are novel exposures; their potential hazardous effects to humans have been under the radar for many years. In this review, we have assessed the association between oral exposure to man-made particles/fibers and genotoxicity in gastrointestinal tract cells and secondary tissues. We identified a total of 137 studies on oral exposure to particles and fibers. This was reduced to 49 papers with sufficient quality and relevance, including exposures to asbestos, diesel exhaust particles, titanium dioxide, silver nanoparticles, zinc oxide, synthetic amorphous silica and certain other nanomaterials. Nineteen studies show positive results, 25 studies show null results, and 5 papers show equivocal results on genotoxicity. Recent studies seem to show null effects, whereas there is a higher proportion of positive genotoxicity results in early studies. Genotoxic effects seem to cluster in studies on diesel exhaust particles and titanium dioxide, whereas studies on silver nanoparticles, zinc oxide and synthetic amorphous silica seem to show mainly null effects. The most widely used genotoxic tests are the alkaline comet assay and micronucleus assay. There are relatively few results on genotoxicity using reliable measurements of oxidatively damaged DNA, DNA double strand breaks (γH2AX assay) and mutations. In general, evidence suggest that oral exposure to particles and fibers is associated with genotoxicity in animals.

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来源期刊
CiteScore
12.20
自引率
1.90%
发文量
22
审稿时长
15.7 weeks
期刊介绍: The subject areas of Reviews in Mutation Research encompass the entire spectrum of the science of mutation research and its applications, with particular emphasis on the relationship between mutation and disease. Thus this section will cover advances in human genome research (including evolving technologies for mutation detection and functional genomics) with applications in clinical genetics, gene therapy and health risk assessment for environmental agents of concern.
期刊最新文献
Emerging pollutants in the aquatic environments: A review of genotoxic impacts State of art of micronuclei assay in exfoliative cytology as a clinical biomarker of genetic damage in oral carcinogenesis: A systematic review and meta-analysis A critical review of the impact of candidate copy number variants on autism spectrum disorder Use of micronucleus cytome assays with buccal cells for the detection of genotoxic effects: A systematic review and meta-analysis of occupational exposures to metals Genome-scale mutational signature analysis in fixed archived tissues
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