腹水效应:发生机制及在转移性癌症治疗中的应用前景

A. V. Khachaturyan, P. V. Bulychkin
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引用次数: 0

摘要

肿瘤学中的腹水效应已有 70 年的历史,但直到最近,其临床意义还很低。免疫反应检查点抑制剂的开发促使人们积极研究这一现象。现在有证据表明,有腹水效应记录的患者生存率有所提高,这为不同阶段癌症的治疗开辟了新的前景。本综述介绍了有关潜逃效应机制的数据、实验和临床数据、目前的局限性以及可能的前景。本研究的目的是调查目前关于腹回声效应发生的概念,并评估利用腹回声效应治疗转移性癌症的前景。材料和方法。我们在 Pubmed 系统中搜索了 2010 年至 2023 年期间的出版物。在286篇文献中,有72篇用于撰写综述。结果。在广泛使用免疫检查点抑制剂(ICIs)治疗癌症的时代,腹水效应似乎是一种有效的治疗方法,在治疗转移性癌症患者方面具有广阔的应用前景。结论随着免疫疗法的出现,腹水效应的发生率有所上升,而 ICIs 与放射治疗(RT)的结合使用甚至改善了晚期患者的生存率。需要开展更多的研究来制定标准化的治疗方案,包括 RT 的最佳剂量和时机,以及与不同类别 ICIs 联合治疗的有效性和安全性。此外,还需要进一步寻找临床和实验室缺氧效应预测指标,以便采取个性化治疗方法。
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The abscopal effect: mechanism of occurrence and prospects of using it in therapy of metastatic cancer
The abscopal effect in oncology has been known for 70 years, but until recently its clinical significance was rather low. The development of immune response checkpoint inhibitors has led to an active study of this phenomenon. There is now evidence of improved survival among patients, in whom the abscopal effect has been documented, opening new perspectives for the treatment of cancers at different stages. This review presents data on the mechanisms of the abscopal effect, experimental and clinical data, current limitations and possible perspectives. The aim of the study was to investigate the current concept of the abscopal effect occurrence and to evaluate the prospects of using the abscopal effect in therapy of metastatic cancer. Material and Methods. We searched publications in Pubmed system from 2010 to 2023. Of 286 publications, 72 were used for writing the review. Results. In the era of widespread use of immune checkpoint inhibitors (ICIs) for cancer therapy, the abscopal effect appears to be an effective therapeutic approach with broad prospects of application in the treatment of patients with metastatic cancer. Conclusion. The incidence of the abscopal effect has increased with the advent of immune therapy, and the use of ICIs with radiation therapy (RT) has shown improved survival even in patients with advanced disease. More research is needed to establish standardized treatment protocols, including the optimal dose and timing of RT, as well as the efficacy and safety of combination therapy with different classes of ICIs. Further search for clinical and laboratory abscopal effect predictors, which could allow personalized treatment approaches, is required.
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来源期刊
Siberian journal of oncology
Siberian journal of oncology Medicine-Oncology
CiteScore
0.40
自引率
0.00%
发文量
117
审稿时长
8 weeks
期刊介绍: The main objectives of the journal are: -to promote the establishment of Russia’s leading worldwide positions in the field of experimental and clinical oncology- to create the international discussion platform intended to cover all aspects of basic and clinical cancer research, including carcinogenesis, molecular biology, epidemiology, cancer prevention, diagnosis and multimodality treatment (surgery, chemotherapy, radiation therapy, hormone therapy), anesthetic management, medical and social rehabilitation, palliative care as well as the improvement of life quality of cancer patients- to encourage promising young scientists to be actively involved in cancer research programs- to provide a platform for researches and doctors all over the world to promote, share, and discuss various new issues and developments in cancer related problems. (to create a communication platform for the expansion of cooperation between Russian and foreign professional associations).- to provide the information about the latest worldwide achievements in different fields of oncology The most important tasks of the journal are: -to encourage scientists to publish their research results- to offer a forum for active discussion on topics of major interest - to invite the most prominent Russian and foreign authors to share their latest research findings with cancer research community- to promote the exchange of research information, clinical experience, current trends and the recent developments in the field of oncology as well as to review interesting cases encountered by colleagues all over the world- to expand the editorial board and reviewers with the involvement of well-known Russian and foreign experts- to provide open access to full text articles- to include the journal into the international database- to increase the journal’s impact factor- to promote the journal to the International and Russian markets
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