Colonoscopy combined with laparoscopy can improve post-operative quality of life in patients with colon cancer

Aim

The study aimed to elucidate the clinical efficacy of colonoscopy combined with laparoscopic radical resection for patients with colon cancer.

Methods

Cases with colon cancer were divided into the control group (received laparoscopic radical resection) and the experimental group (received colonoscopy combined with laparoscopic radical resection). Inflammatory cytokines’ levels and immune functions were evaluated before and after the operation. The 36-item Short Form Health Survey (SF-36) was used to evaluate the living quality.

Results

Relative to the control group, individuals in the experimental group had a shorter hospital stay and post-operative anal exhaust, and reduced intraoperative blood loss. Changes in serum interferon-gamma (IFN-γ), interleukin-8 (IL-8) and IL-10 levels were minimal in the experimental group. Serum CD3⁺%, CD4⁺% and CD4⁺/CD8⁺ values of the two groups were significantly decreased compared with the preoperative values, which increased more significantly in the experimental group relative to the control group. After the operation, individuals in the experimental group presented higher SF-36 scores than those in the experimental group. The experimental group presented a low incidence of post-operative complications.

Conclusions

Colonoscopy combined with laparoscopic radical resection for colon cancer had only a little effect on immune function and inflammatory response. It can shorten the recovery time of patients and reduce post-operative complications, which is worthy of further clinical promotion.