在氯化锌/脲深共晶溶剂中偶然合成 2,3-二氢喹唑啉-4(1H)-酮

IF 0.8 4区化学 Q4 CHEMISTRY, ORGANIC Arkivoc Pub Date : 2024-03-16 DOI:10.24820/ark.5550190.p012.167

Parvesh Singh, Gobind Kumar, L. Khubone, P. Seboletswe, Neha Manhas, Talent R. Makhanya, Gaurav Bhargava

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引用次数: 0

摘要

本研究开发了一种绿色、可持续和高效的单锅合成 2,3-二氢喹唑啉-4(1 H )- 1（DHQs）的合成策略。用作深共晶溶剂（DES）的 ZnCl 2 /尿素不仅有效地促进了异酸酐和苯甲醛之间的缩合，还意外地在 sit u 中充当了氮源（如氨）的角色，从而以优异的产率获得了 DHQs。这种方法具有显著的优势，包括 DES 在 DHQs 合成中的三重作用、原子经济的绿色有机催化剂、无金属条件、成本效益以及对一系列官能团的耐受性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Serendipitous synthesis of 2,3-Dihydroquinazolin-4(1H)-ones in ZnCl2/Urea deep eutectic solvent

A green, sustainable, and efficient one-pot, synthetic strategy for the synthesis of 2,3-dihydroquinazolin-4(1 H )- ones (DHQs) was developed. The ZnCl 2 /urea used as a deep eutectic solvent (DES) not only efficiently promoted the condensation between isatoic anhydride and benzaldehyde but unexpectedly acted as a nitrogen source (like ammonia) in sit u to afford DHQs in excellent yields. This approach offers remarkable advantages, involving the triple role of DES in the synthesis of DHQs, atom-economical, green organocatalysts, metal-free conditions, cost-effectiveness, and tolerance to a range of functional groups

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来源期刊

Arkivoc 化学-有机化学

CiteScore

1.10

自引率

11.10%

发文量

120

审稿时长

3.1 months

期刊介绍： Arkivoc publishes full papers (not accounts) describing sound original work that is of interest to organic chemists (in areas of synthetic organic chemistry, bio-organic, organometallic, theoretical, and physical organic chemistry: General Papers describing sound original work Reviews and Accounts of selected topics Honorary Issues - Pay tribute to distinguished organic chemists (invited contributions) Thematic Issues - Cover important current topics in organic chemistry Regional Issues - Recognize organic chemistry in various countries.