线场共焦光学相干断层成像中样品和浸入介质之间折射率失配的影响

IF 1.9 4区 物理与天体物理 Q3 OPTICS Journal of the European Optical Society-Rapid Publications Pub Date : 2024-03-15 DOI:10.1051/jeos/2024010
Arnaud Dubois
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引用次数: 0

摘要

线场共焦光学相干断层成像(LC-OCT)是一种基于线照明低相干干涉显微镜的光学技术,设计用于对具有微米级空间分辨率的半透明样品进行断层成像。本文介绍了 LC-OCT 采集信号的理论模型。该模型表明,样品和浸入介质之间的折射率失配会导致相干平面和焦平面分离,从而导致信号振幅下降和图像横向分辨率降低。测量结果验证并说明了理论预测。建立了一个连接各种实验参数的数学条件,以确保图像质量的下降可以忽略不计。该条件通过对幻影成像进行实验测试。使用与市售 LC-OCT 设备相应的实验参数,对皮肤成像进行了理论验证。
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Effects of refractive index mismatch between sample and immersion medium in line-field confocal optical coherence tomography
Line-field confocal optical coherence tomography (LC-OCT) is an optical technique based on low-coherence interference microscopy with line illumination, designed for tomographic imaging of semi-transparent samples with micrometer-scale spatial resolution. A theoretical model of the signal acquired in LC-OCT is presented. The model shows that a refractive index mismatch between the sample and the immersion medium causes a dissociation of the coherence plane and the focal plane, leading to a decrease in the signal amplitude and a degradation of the image’s lateral resolution. Measurements are performed to validate and illustrate the theoretical predictions. A mathematical condition linking various experimental parameters is established to ensure that the degradation of image quality is negligible. This condition is tested experimentally by imaging a phantom. It is verified theoretically in the case of skin imaging, using experimental parameters corresponding to those of the commercially available LC-OCT device.
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来源期刊
CiteScore
2.40
自引率
0.00%
发文量
12
审稿时长
5 weeks
期刊介绍: Rapid progress in optics and photonics has broadened its application enormously into many branches, including information and communication technology, security, sensing, bio- and medical sciences, healthcare and chemistry. Recent achievements in other sciences have allowed continual discovery of new natural mysteries and formulation of challenging goals for optics that require further development of modern concepts and running fundamental research. The Journal of the European Optical Society – Rapid Publications (JEOS:RP) aims to tackle all of the aforementioned points in the form of prompt, scientific, high-quality communications that report on the latest findings. It presents emerging technologies and outlining strategic goals in optics and photonics. The journal covers both fundamental and applied topics, including but not limited to: Classical and quantum optics Light/matter interaction Optical communication Micro- and nanooptics Nonlinear optical phenomena Optical materials Optical metrology Optical spectroscopy Colour research Nano and metamaterials Modern photonics technology Optical engineering, design and instrumentation Optical applications in bio-physics and medicine Interdisciplinary fields using photonics, such as in energy, climate change and cultural heritage The journal aims to provide readers with recent and important achievements in optics/photonics and, as its name suggests, it strives for the shortest possible publication time.
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