染色质马达复合物如何影响核结构?染色质组织、聚合素和凝集素综述(以秀丽隐杆线虫为重点

DNA Pub Date : 2024-03-11 DOI:10.3390/dna4010005
Bahaar Chawla, G. Csankovszki
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引用次数: 0

摘要

染色质是生物体细胞核中的 DNA 和相关蛋白质的复合体。染色质如何组织是一个重要的研究领域,因为它对复制、修复和基因表达都有影响。这篇综述总结了染色质组织领域的现状,特别关注染色质运动复合物凝聚素和凝集素。这些复合体包含高度保守的 SMC 蛋白,负责在细胞分裂过程中组织染色质。此外,研究表明,凝集素和凝聚素在细胞间期也具有重要功能,可塑造染色质的组织结构并调控基因的表达。作者以模式生物 elegans 为例,回顾了这些复合体如何发挥如此多样作用的现有知识,以及该领域还存在哪些未决问题。
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How Chromatin Motor Complexes Influence the Nuclear Architecture: A Review of Chromatin Organization, Cohesins, and Condensins with a Focus on C. elegans
Chromatin is the complex of DNA and associated proteins found in the nuclei of living organisms. How it is organized is a major research field as it has implications for replication, repair, and gene expression. This review summarizes the current state of the chromatin organization field, with a special focus on chromatin motor complexes cohesin and condensin. Containing the highly conserved SMC proteins, these complexes are responsible for organizing chromatin during cell division. Additionally, research has demonstrated that condensin and cohesin also have important functions during interphase to shape the organization of chromatin and regulate expression of genes. Using the model organism C. elegans, the authors review the current knowledge of how these complexes perform such diverse roles and what open questions still exist in the field.
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