小儿炎症性肠病的成像和内窥镜工具:有什么新进展?

Alexandra S Hudson, G. T. Wahbeh, Hengqi Betty Zheng
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摘要

小儿炎症性肠病(IBD)是一种慢性炎症性疾病,在全世界的发病率和流行率都在不断上升。近年来,用于疾病诊断、治疗和监测的成像和内窥镜技术取得了长足的进步。肠道超声,包括经腹、经会阴和内窥镜超声,已开始用于评估跨膜肠道炎症和疾病并发症(如瘘管、脓肿)。除手术外,与 IBD 相关的肠道狭窄现在也有内镜治疗方法可供选择,包括镜下球囊扩张术、注射和针刀狭窄切除术,以及新的评估工具,如内镜功能性管腔成像探针。对于上消化道克罗恩病患者或伴有新的上消化道症状的 IBD 患者,无隔热经鼻内镜检查可能会发挥作用。随着虚拟色内镜的加入和人工智能辅助内镜检测领域的持续研究,长期结肠疾病或原发性硬化性胆管炎儿科患者的发育不良筛查有望得到改善。人工智能和机器学习是一个快速发展的领域,其目标是进一步个性化 IBD 诊断、治疗选择和预后判断。本综述总结了这些进展,重点关注儿童 IBD 患者。
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Imaging and endoscopic tools in pediatric inflammatory bowel disease: What’s new?
Pediatric inflammatory bowel disease (IBD) is a chronic inflammatory disorder, with increasing incidence and prevalence worldwide. There have been recent advances in imaging and endoscopic technology for disease diagnosis, treatment, and monitoring. Intestinal ultrasound, including transabdominal, transperineal, and endoscopic, has been emerging for the assessment of transmural bowel inflammation and disease complications (e.g., fistula, abscess). Aside from surgery, IBD-related intestinal strictures now have endoscopic treatment options including through-the-scope balloon dilatation, injection, and needle knife stricturotomy and new evaluation tools such as endoscopic functional lumen imaging probe. Unsedated transnasal endoscopy may have a role in patients with upper gastrointestinal Crohn’s disease or those with IBD with new upper gastrointestinal symptoms. Improvements to dysplasia screening in pediatric patients with longstanding colonic disease or primary sclerosing cholangitis hold promise with the addition of virtual chromoendoscopy and ongoing research in the field of artificial intelligence-assisted endoscopic detection. Artificial intelligence and machine learning is a rapidly evolving field, with goals of further personalizing IBD diagnosis and treatment selection as well as prognostication. This review summarized these advancements, focusing on pediatric patients with IBD.
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