Larisa M. Musaeva, Yulia A. Prokofeva, I. Menshikova, Aishat E. Rasulova
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The patients underwent clinical, laboratory and instrumental examinations (Tender Joint Count (TJC) and Swollen Joint Count (SJC), common blood test with differential white blood cell count, ESR, biochemical blood test, CRP, RF, ACCP, hands, feet and chest X-ray, ECG). RA activity was assessed using DAS28, CDAI, SDAI indices in both groups. \nResults. RA activity control after 12 months in patients of the first group regularly observed by a rheumatologist was better than in patients of the second group, who visited rheumatologist again only in 12 months. DAS28 decreased significantly, from 4.71±0.80 to 3.08±0.70 in the group with regular monitoring during the observation period. Remission or low activity was achieved by 75% of patients (5% remission and 70% low activity). Less dynamics was registered in patients of the second group: the initial DAS28 was 4.50±0.74, DAS28 after 12 months was 4.36±0.64, which corresponds to moderate activity. Low activity was achieved in 15% of patients, remission was not achieved in any patient. \nConclusion. Strict adherence to the recommended terms for disease activity monitoring is necessary for successful RA treatment in real clinical practice.","PeriodicalId":10550,"journal":{"name":"Consilium Medicum","volume":"21 2","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The role of timely rheumatoid arthritis treatment effectiveness control\",\"authors\":\"Larisa M. Musaeva, Yulia A. Prokofeva, I. Menshikova, Aishat E. Rasulova\",\"doi\":\"10.26442/20751753.2023.11.202606\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background. Regular assessment of rheumatoid arthritis (RA) activity is a key factor in therapy effectiveness improving. \\nAim. To prove that timely RA treatment control recommended by modern guidelines improves outcomes and reduce disability in real clinical practice. \\nMaterials and methods. Fourty patients with RA hospitalized at the University Clinical Hospital from January 2021 to January 2023 were included into a retrospective single-center study and divided into 2 groups. In the first group, RA activity was monitored after 3, 6, and 12 months, with therapy adjusted if necessary. In the second group, monitoring of RA activity was carried out after 12 months. The patients underwent clinical, laboratory and instrumental examinations (Tender Joint Count (TJC) and Swollen Joint Count (SJC), common blood test with differential white blood cell count, ESR, biochemical blood test, CRP, RF, ACCP, hands, feet and chest X-ray, ECG). RA activity was assessed using DAS28, CDAI, SDAI indices in both groups. \\nResults. RA activity control after 12 months in patients of the first group regularly observed by a rheumatologist was better than in patients of the second group, who visited rheumatologist again only in 12 months. DAS28 decreased significantly, from 4.71±0.80 to 3.08±0.70 in the group with regular monitoring during the observation period. Remission or low activity was achieved by 75% of patients (5% remission and 70% low activity). Less dynamics was registered in patients of the second group: the initial DAS28 was 4.50±0.74, DAS28 after 12 months was 4.36±0.64, which corresponds to moderate activity. Low activity was achieved in 15% of patients, remission was not achieved in any patient. \\nConclusion. 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引用次数: 0
摘要
背景。定期评估类风湿关节炎(RA)的活动是提高治疗效果的关键因素。目的证明在实际临床实践中,现代指南所建议的及时控制 RA 治疗可提高疗效并减少残疾。材料和方法。将 2021 年 1 月至 2023 年 1 月期间在大学临床医院住院的 40 例 RA 患者纳入回顾性单中心研究,并将其分为 2 组。第一组在 3 个月、6 个月和 12 个月后监测 RA 活动,必要时调整治疗方案。第二组在 12 个月后监测 RA 活动。患者接受了临床、实验室和仪器检查(关节触痛计数(TJC)和关节肿胀计数(SJC)、普通血液检查和白细胞计数差值、血沉、生化血液检查、CRP、RF、ACCP、手部、足部和胸部 X 光检查、心电图)。使用 DAS28、CDAI 和 SDAI 指数评估两组患者的 RA 活动性。结果显示12个月后,第一组定期接受风湿免疫科医生观察的患者的RA活动控制情况优于第二组患者,后者在12个月后才再次接受风湿免疫科医生的观察。在观察期间接受定期监测的组别中,DAS28 从(4.71±0.80)明显降低到(3.08±0.70)。75%的患者达到了缓解或低活动度(5%缓解,70%低活动度)。第二组患者的动态变化较小:最初的 DAS28 为 4.50±0.74,12 个月后的 DAS28 为 4.36±0.64,相当于中度活动。15%的患者达到低度活动,没有任何患者达到缓解。结论在实际临床实践中,严格遵守推荐的疾病活动监测条件是成功治疗RA的必要条件。
The role of timely rheumatoid arthritis treatment effectiveness control
Background. Regular assessment of rheumatoid arthritis (RA) activity is a key factor in therapy effectiveness improving.
Aim. To prove that timely RA treatment control recommended by modern guidelines improves outcomes and reduce disability in real clinical practice.
Materials and methods. Fourty patients with RA hospitalized at the University Clinical Hospital from January 2021 to January 2023 were included into a retrospective single-center study and divided into 2 groups. In the first group, RA activity was monitored after 3, 6, and 12 months, with therapy adjusted if necessary. In the second group, monitoring of RA activity was carried out after 12 months. The patients underwent clinical, laboratory and instrumental examinations (Tender Joint Count (TJC) and Swollen Joint Count (SJC), common blood test with differential white blood cell count, ESR, biochemical blood test, CRP, RF, ACCP, hands, feet and chest X-ray, ECG). RA activity was assessed using DAS28, CDAI, SDAI indices in both groups.
Results. RA activity control after 12 months in patients of the first group regularly observed by a rheumatologist was better than in patients of the second group, who visited rheumatologist again only in 12 months. DAS28 decreased significantly, from 4.71±0.80 to 3.08±0.70 in the group with regular monitoring during the observation period. Remission or low activity was achieved by 75% of patients (5% remission and 70% low activity). Less dynamics was registered in patients of the second group: the initial DAS28 was 4.50±0.74, DAS28 after 12 months was 4.36±0.64, which corresponds to moderate activity. Low activity was achieved in 15% of patients, remission was not achieved in any patient.
Conclusion. Strict adherence to the recommended terms for disease activity monitoring is necessary for successful RA treatment in real clinical practice.