未结合高胆红素血症新生儿换血的风险因素:一家三级医院的研究。

Unconjugated Hyperbilirubinemia, Sidrah Yousaf, Uzma Abid, Sughra Zulfiqar, Tehreem Fatima, Ayesha Afzal
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引用次数: 0

摘要

目的评估一家三级医院中患有未结合高胆红素血症的新生儿需要换血的比例,并确定与换血相关的风险因素。研究设计:横断面比较。研究地点拉瓦尔品第圣家医院新生儿科。时间: 2022 年 1 月至 2022 年 12 月2022 年 1 月至 2022 年 12 月。材料与方法通过非概率连续抽样,共纳入 136 名妊娠 28 周至出生后 28 天内患有严重病理性高胆红素血症、非结合性高胆红素血症和或有核黄疸症状的新生儿。然后根据是否接受换血将患者分为两组。采用 SPSS 26 版进行数据录入和分析,并应用描述性和推断性统计。结果共招募了 136 名新生儿,其中男性占 57%(n=78),女性占 43%(n=58)。平均胎龄为 36.6 ± 1.9 周。111名(82%)新生儿为足月儿,25名(18%)为早产儿。研究对象的平均年龄为(6.0±3.3)天,平均体重为(2.7±0.7)公斤。STB 平均水平为 20.8 ± 5.5 mg/dl。64.7%(88 例)需要换血的患者属于 A 组,35.3%(48 例)无需换血的患者属于 B 组。计算得出的疾病负担率为 64.7%。多血症、ABO和Rh血型不合被认为是ET的重要风险因素(P<0.05)。结论发病率为 64.7%。大多数患有未结合高胆红素血症的新生儿需要进行换血。新生儿需要换血的风险因素包括多血症、ABO和Rh血型不合。
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Risk factors for exchange transfusion in neonates with unconjugated hyperbilirubinemia: A tertiary care hospital study.
Objective: To assess the prevalence of exchange transfusion requirement and identify risk factors associated with exchange transfusion in neonates with unconjugated hyperbilirubinemia in a tertiary care hospital. Study Design: Comparative Cross-sectional. Setting: Department of Neonatology, Holy Family Hospital Rawalpindi. Period: January 2022 to December 2022. Material & Methods: A total of 136 neonates, from 28 weeks of gestation to 28 days of life after birth, with severe pathological hyperbilirubinemia, unconjugated hyperbilirubinemia and or who had signs of kernicterus were included through non-probability consecutive sampling. Patients were then divided in to two groups based on exchange transfusion received or not. SPSS version 26 was used for data entry and analysis, and descriptive and inferential statistics were applied. Results: A total of 136 neonates were recruited, out of which 57% (n=78) were male and 43% (n=58) were female. The average gestational age was 36.6 ± 1.9 weeks. 111 (82%) neonates were term, while 25 (18%) were preterm. The average age of the study population was 6.0±3.3 days, with a mean weight of 2.7 ± 0.7 kg. The average STB level was 20.8 ± 5.5 mg/dl. 64.7% (n=88) required exchange transfusion were belonged to group-A, while 35.3 %(n=48) without exchange transfusion were in group-B. The burden of disease was calculated to be 64.7%. Polycythemia, ABO and Rh incompatibility were identified as significant risk factors for ET (p<0.05). Conclusion: The burden of disease was 64.7%. Exchange transfusion was required in the majority of neonates with unconjugated hyperbilirubinemia. The identified risk factors for the requirement of exchange transfusion in neonates were polycythemia, ABO and Rh incompatibility.
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