Doris Steinemann, M. Dawidowska, Lisa J Russell, Christine J Harrison, Gudrun Göhring
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引用次数: 0
摘要
我们根据世界卫生组织（WHO）2024 年发布的第五版血液淋巴肿瘤分类（WHO-HAEM5），为分析淋巴母细胞白血病/淋巴瘤的遗传学问题提供了实用指南。WHO-HAEM5承认遗传学在淋巴肿瘤诊断中的重要性与日俱增。其分类依据的是根据细胞系确定的遗传亚型，先是前体细胞肿瘤，然后是成熟的恶性肿瘤。本指南描述了急性前体 B 细胞和 T 细胞肿瘤的基因异常，这些异常是进行风险分层和治疗所必需的，并在 "必要 "和 "理想 "诊断标准标题下提供了诊断算法。
Genetic alterations in lymphoblastic leukaemia / lymphoma – a practical guide to WHO HAEM5
We present a practical guide for analyzing the genetic aspects of lymphoblastic leukaemia/lymphoma according to the 5th edition of the World Health Organization (WHO) classification of haematolymphoid neoplasms (WHO-HAEM5) issued in 2024. The WHO-HAEM5 acknowledges the increasing importance of genetics in the diagnosis of lymphoid neoplasia. Classification is based on the established genetic subtypes according to cell lineage, with precursor cell neoplasms followed by mature malignancies. This guide describes those genetic abnormalities in acute precursor B- and T-cell neoplasms required for risk stratification, and for treatment, providing diagnostic algorithms under the headings of ‘essential’ and ‘desirable’ diagnostic criteria.
期刊介绍：
medizinischegenetik is a scientific journal that is owned and published by the German Society of Human Genetics e.V. since 1989. The journal was founded by Prof. Jan Murken, München. Self-published until 2006, from 2007-2019 published at Springer Verlag and since 2020 at De Gruyter.
medizinischegenetik serves education and training among colleagues, the interdisciplinary exchange of knowledge in all areas of human genetics in clinics, practice, research and teaching. Each issue of the quarterly journal deals with a focus that provides a comprehensive overview of current developments in specific clinical pictures, technical developments and therapeutic approaches. All reviews are written in English language. The journal thus creates a platform for the international exchange of knowledge and increased awareness of German research activities in the scientific community.
In addition, medizinischegenetik contains information on activities in its own subject in the German-language section. This includes conference reports, association announcements, personnel matters, statements and guidelines. With health policy questions, historical retrospectives and comments on current developments, the profession takes a stand on human genetic issues in Germany, Austria and Switzerland.
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