根据 Goh 等人的标准，诊断为 SSc-EPID 时局限性硬皮病与广泛性硬皮病间质性肺病的患病率。

IF 2.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL Revista clinica espanola Pub Date : 2024-04-01 DOI:10.1016/j.rce.2024.02.002

M. Rubio-Rivas , M. Pestaña-Fernández

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引用次数: 0

摘要

导言Goh等人于2008年提出了一种局限性或广泛性SSc-ILD的分类算法。方法通过 2008 年至 2023 年的 MEDLINE 和 SCOPUS，使用 "系统性"、"硬皮病 "或 "间质性肺病"[MesH]等术语进行回顾："系统性"、"硬皮病 "或 "间质性肺病"[MesH]。观察性研究采用纽卡斯尔-渥太华量表（Newcastle-Ottawa Scale）进行合格评估，临床试验采用贾达德量表（Jadad Scale）进行合格评估。结果最初有 27 项研究被纳入系统综述和荟萃分析 (SRMA)。其中，17 项研究的数据没有重叠。这些研究报告了 2,149 名患者的数据，其中 1,369 名患者（81.2%）为女性。平均年龄为 52.4 (SD 6.6)岁。45.2%的患者属于弥漫性亚型，54.8%的患者属于局限性或正弦硬皮病亚型。38.7%的患者抗异构酶抗体呈阳性，14.2%的患者抗中心粒抗体呈阳性。基线强迫生命容量的平均百分比为 80.5%（标准差 6.9），肺部一氧化碳弥散容量的平均百分比为 59.1%（标准差 9.6）。12项研究提供了经PFT调整的SSc-ILD扩展数据，并被纳入荟萃分析。对 10 项观察性队列研究进行了单独分析。采用随机效应模型，估计受限扩展的总比例为 63.5%（95%CI 55.3-73；p <0.001）。采用随机效应模型，研究之间的异质性（I2）为 9.8% (95%CI 0-68.2%)。肺部广泛受累的比例估计为 34.3% (95%CI 26-45.4; p < 0.001)。结论在诊断为SSc-ILD时，局限性SSc-ILD的总比例估计为63.5%，广泛性为34.3%。

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Prevalencia de la enfermedad pulmonar esclerodermia-intersticial limitada frente a la extensa en el momento del diagnóstico de SSc-EPID según los criterios de Goh et al. Revisión sistemática y metaanálisis

Introduction

Goh et al. proposed in 2008 a classificatory algorithm of limited or extensive SSc-ILD. The prevalence of both at the time of diagnosis of SSc-ILD is not known with exactitude.

Methods

The review was undertaken by means of MEDLINE and SCOPUS from 2008 to 2023 and using the terms: “systemic”, “scleroderma” or “interstitial lung disease” [MesH]. The Newcastle-Ottawa Scale was used for the qualifying assessment for observational studies and the Jadad scale for clinical trials. The inverse variance-weighted method was performed.

Results

Twenty-seven studies were initially included in the systematic review and meta-analysis (SRMA). Of these, 17 studies had no overlapping data. They reported data from 2,149 patients, 1,369 (81.2%) were female. The mean age was 52.4 (SD 6.6) years. 45.2% of the patients had the diffuse subtype and 54.8% had the limited or sine scleroderma subtype. A total of 38.7% of the patients showed positive antitopoisomerase antibodies and 14.2% positive anticentromere antibodies. The mean percentage of forced vital capacity at baseline was 80.5% (SD 6.9) and of diffusing capacity of the lungs for carbon monoxide was 59.1% (SD 9.6). Twelve studies presented SSc-ILD extension data adjusted for PFTs and were included in the meta-analysis. The 10 observational cohort studies were analyzed separately. The overall percentage of limited extension was estimated at 63.5% (95%CI 55.3–73; p < 0.001) using the random-effects model. Heterogeneity between studies (I²) was 9.8% (95%CI 0–68.2%) with the random-effects model. Extensive pulmonary involvement was estimated at 34.3% (95%CI 26–45.4; p < 0.001). Heterogeneity between studies (I²) was 0% (95%CI 0–61.6%) with the random-effects model.

Conclusion

The overall percentage of limited SSc-ILD at the time of diagnosis of SSc-ILD was estimated at 63.5% and extensive at 34.3%.

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来源期刊

Revista clinica espanola 医学-医学：内科

CiteScore

4.40

自引率

6.90%

发文量

审稿时长

28 days

期刊介绍： Revista Clínica Española published its first issue in 1940 and is the body of expression of the Spanish Society of Internal Medicine (SEMI). The journal fully endorses the goals of updating knowledge and facilitating the acquisition of key developments in internal medicine applied to clinical practice. Revista Clínica Española is subject to a thorough double blind review of the received articles written in Spanish or English. Nine issues are published each year, including mostly originals, reviews and consensus documents.