巨噬细胞迁移抑制因子 (MIF):在认知障碍疾病中的潜在作用

IF 9.3 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Cytokine & Growth Factor Reviews Pub Date : 2024-06-01 DOI:10.1016/j.cytogfr.2024.03.003
Lian Zeng , Pengchao Hu , Yu Zhang , Mingyue Li , Yilin Zhao , Shiyong Li , Ailin Luo
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引用次数: 0

摘要

巨噬细胞迁移抑制因子(MIF)是免疫系统中的一种细胞因子,参与先天性和适应性免疫反应。除免疫细胞外,多种非免疫细胞也会分泌 MIF,包括造血细胞、内皮细胞(EC)和神经元。MIF 在败血症、类风湿性关节炎、急性肾损伤和神经退行性疾病等多种疾病中发挥着重要作用。MIF 在认知障碍疾病的神经发病机制中的作用得到了强调,因为它能招募多种炎症介质,导致激活小胶质细胞或星形胶质细胞衍生的神经炎症。此外,它还会通过parthanatos-associated apoptosis-inducing factor nuclease (PAAN) / MIF途径与凋亡诱导因子(AIF)结合,导致神经元和EC的细胞死亡。本综述全面探讨了 MIF 与认知障碍疾病的神经发病机制之间的关系,并提供了一系列新兴的 MIF 靶向药物,作为认知障碍疾病的潜在治疗方法。
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Macrophage migration inhibitor factor (MIF): Potential role in cognitive impairment disorders

Macrophage migration inhibitory factor (MIF) is a cytokine in the immune system, participated in both innate and adaptive immune responses. Except from immune cells, MIF is also secreted by a variety of non-immune cells, including hematopoietic cells, endothelial cells (ECs), and neurons. MIF plays a crucial role in various diseases, such as sepsis, rheumatoid arthritis, acute kidney injury, and neurodegenerative diseases. The role of MIF in the neuropathogenesis of cognitive impairment disorders is emphasized, as it recruits multiple inflammatory mediators, leading to activating microglia or astrocyte-derived neuroinflammation. Furthermore, it contributes to the cell death of neurons and ECs with the binding of apoptosis-inducing factor (AIF) through parthanatos-associated apoptosis-inducing factor nuclease (PAAN) / MIF pathway. This review comprehensively delves into the relationship between MIF and the neuropathogenesis of cognitive impairment disorders, providing a series of emerging MIF-targeted pharmaceuticals as potential treatments for cognitive impairment disorders.

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来源期刊
Cytokine & Growth Factor Reviews
Cytokine & Growth Factor Reviews 生物-生化与分子生物学
CiteScore
21.10
自引率
1.50%
发文量
61
审稿时长
22 days
期刊介绍: Cytokine & Growth Factor Reviews is a leading publication that focuses on the dynamic fields of growth factor and cytokine research. Our journal offers a platform for authors to disseminate thought-provoking articles such as critical reviews, state-of-the-art reviews, letters to the editor, and meeting reviews. We aim to cover important breakthroughs in these rapidly evolving areas, providing valuable insights into the multidisciplinary significance of cytokines and growth factors. Our journal spans various domains including signal transduction, cell growth and differentiation, embryonic development, immunology, tumorigenesis, and clinical medicine. By publishing cutting-edge research and analysis, we aim to influence the way researchers and experts perceive and understand growth factors and cytokines. We encourage novel expressions of ideas and innovative approaches to organizing content, fostering a stimulating environment for knowledge exchange and scientific advancement.
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