E. Loginova, P. Tremaskina, E. Gubar, T. Korotaeva, A. Sukhinina, S. Glukhova
{"title":"早期银屑病关节炎患者 7 年的骶髂关节影像学进展(初步结果)","authors":"E. Loginova, P. Tremaskina, E. Gubar, T. Korotaeva, A. Sukhinina, S. Glukhova","doi":"10.47360/1995-4484-2024-98-103","DOIUrl":null,"url":null,"abstract":"Objective – to assess the dynamics of the sacroiliac joint radiographic progression (X-SIJ) in early psoriatic arthritis (ePsA).Methods. 32 patients (pts) (19 men and 13 women) with PsA were examined at baseline (BL) and after 7 years. Mean age – 43.9±12 years, Me PsA duration – 7.5 [6; 8.25] years, follow-up – 7 [5.75; 7.83] years. All patients received standard treatment using biologic therapy in 59.4% of cases, mainly with tumor necrosis factor α (TNF-α) inhibitors (43.7%). Radiographs of sacroiliac joint (SIJ) at BL and after 7 years were evaluated by an independent reader by Kellgren. Sacroiliitis (SI) on radiografhy (rSI) was recorded if there were changes in at least one SIJ grade II or higher. SI was considered radiologically significant (r-sSI) when it was bilateral grade II or higher, or unilateral grade III or IV. Progression was defined as the sift by ≥1 grade on any side.Results. At BL SI was not observed in 11 (34.3%) pts, SI grade I was present in 7 (21.9%) pts, grade II – in 10 (31.3%), grade III – in 4 (12.5%). After 7 years SI was not observed in 6 (18.75%) pts, SI grade I was present in 6 (18.75%) pts, grade II – in 8 (25%), grade III – in 8 (25%), grade IV – in 4 (12.5%). At BL rSI was registered in 14 (43.75%) patients, after 7 years the number of patients with rSI increased to 20 (62.5%). At BL and 7 years follow-up r-sSI was detected in 10 (31.3%) and 16 (50%) pts (p=0.128). On each side X-SIJ progression was detected in 15 (46.9%) pts (at 1 grade – in 10, 2 grades – in 1, 3 grades – in 4), 1 patient showed a decrease at 1 grade (from III to II).Conclusion. In ePsA radiographic progression of SI is slow. Dactylitis, high CRP, and lack of iTNF-α therapy are associated with radiographic progression.","PeriodicalId":21518,"journal":{"name":"Rheumatology Science and Practice","volume":"293 3","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"7 year of sacroiliac radiographic progression in early psoriatic arthritis (preliminary results)\",\"authors\":\"E. Loginova, P. Tremaskina, E. Gubar, T. Korotaeva, A. Sukhinina, S. Glukhova\",\"doi\":\"10.47360/1995-4484-2024-98-103\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective – to assess the dynamics of the sacroiliac joint radiographic progression (X-SIJ) in early psoriatic arthritis (ePsA).Methods. 32 patients (pts) (19 men and 13 women) with PsA were examined at baseline (BL) and after 7 years. Mean age – 43.9±12 years, Me PsA duration – 7.5 [6; 8.25] years, follow-up – 7 [5.75; 7.83] years. All patients received standard treatment using biologic therapy in 59.4% of cases, mainly with tumor necrosis factor α (TNF-α) inhibitors (43.7%). Radiographs of sacroiliac joint (SIJ) at BL and after 7 years were evaluated by an independent reader by Kellgren. Sacroiliitis (SI) on radiografhy (rSI) was recorded if there were changes in at least one SIJ grade II or higher. SI was considered radiologically significant (r-sSI) when it was bilateral grade II or higher, or unilateral grade III or IV. Progression was defined as the sift by ≥1 grade on any side.Results. At BL SI was not observed in 11 (34.3%) pts, SI grade I was present in 7 (21.9%) pts, grade II – in 10 (31.3%), grade III – in 4 (12.5%). After 7 years SI was not observed in 6 (18.75%) pts, SI grade I was present in 6 (18.75%) pts, grade II – in 8 (25%), grade III – in 8 (25%), grade IV – in 4 (12.5%). At BL rSI was registered in 14 (43.75%) patients, after 7 years the number of patients with rSI increased to 20 (62.5%). At BL and 7 years follow-up r-sSI was detected in 10 (31.3%) and 16 (50%) pts (p=0.128). On each side X-SIJ progression was detected in 15 (46.9%) pts (at 1 grade – in 10, 2 grades – in 1, 3 grades – in 4), 1 patient showed a decrease at 1 grade (from III to II).Conclusion. In ePsA radiographic progression of SI is slow. Dactylitis, high CRP, and lack of iTNF-α therapy are associated with radiographic progression.\",\"PeriodicalId\":21518,\"journal\":{\"name\":\"Rheumatology Science and Practice\",\"volume\":\"293 3\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Rheumatology Science and Practice\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.47360/1995-4484-2024-98-103\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Rheumatology Science and Practice","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.47360/1995-4484-2024-98-103","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
目的--评估早期银屑病关节炎(ePsA)骶髂关节放射学进展(X-SIJ)的动态变化。32名PsA患者(pts)(19名男性和13名女性)在基线(BL)和7年后接受了检查。平均年龄(43.9±12)岁,PsA病程-7.5 [6; 8.25]年,随访-7 [5.75; 7.83]年。所有患者均接受了标准治疗,其中59.4%的病例使用了生物疗法,主要是肿瘤坏死因子α(TNF-α)抑制剂(43.7%)。骶髂关节(SIJ)在BL期和7年后的X光片由一名独立的Kellgren读片员进行评估。如果至少有一个骶髂关节出现二级或二级以上的变化,则记录为放射学上的骶髂关节炎(SI)(rSI)。当 SI 为双侧 II 级或以上,或单侧 III 级或 IV 级时,则被认为具有放射学意义(r-sSI)。任何一侧的SI≥1级即为进展。11 名患者(34.3%)在基础阶段未观察到 SI,7 名患者(21.9%)出现 I 级 SI,10 名患者(31.3%)出现 II 级 SI,4 名患者(12.5%)出现 III 级 SI。7 年后,6 名患者(18.75%)未观察到 SI,6 名患者(18.75%)出现 I 级 SI,8 名患者(25%)出现 II 级 SI,8 名患者(25%)出现 III 级 SI,4 名患者(12.5%)出现 IV 级 SI。有 14 名患者(43.75%)在基础阶段出现了 rSI,7 年后,出现 rSI 的患者增至 20 名(62.5%)。在 BL 和 7 年的随访中,分别有 10 名(31.3%)和 16 名(50%)患者检测到 r-SSI(P=0.128)。15例(46.9%)患者的两侧X-SIJ均有进展(10例为1级,1例为2级,4例为3级),1例患者的X-SIJ下降了1级(从III级降至II级)。在 ePsA 中,SI 的放射学进展缓慢。双下肢炎、高 CRP 和缺乏 iTNF-α 治疗与影像学进展有关。
7 year of sacroiliac radiographic progression in early psoriatic arthritis (preliminary results)
Objective – to assess the dynamics of the sacroiliac joint radiographic progression (X-SIJ) in early psoriatic arthritis (ePsA).Methods. 32 patients (pts) (19 men and 13 women) with PsA were examined at baseline (BL) and after 7 years. Mean age – 43.9±12 years, Me PsA duration – 7.5 [6; 8.25] years, follow-up – 7 [5.75; 7.83] years. All patients received standard treatment using biologic therapy in 59.4% of cases, mainly with tumor necrosis factor α (TNF-α) inhibitors (43.7%). Radiographs of sacroiliac joint (SIJ) at BL and after 7 years were evaluated by an independent reader by Kellgren. Sacroiliitis (SI) on radiografhy (rSI) was recorded if there were changes in at least one SIJ grade II or higher. SI was considered radiologically significant (r-sSI) when it was bilateral grade II or higher, or unilateral grade III or IV. Progression was defined as the sift by ≥1 grade on any side.Results. At BL SI was not observed in 11 (34.3%) pts, SI grade I was present in 7 (21.9%) pts, grade II – in 10 (31.3%), grade III – in 4 (12.5%). After 7 years SI was not observed in 6 (18.75%) pts, SI grade I was present in 6 (18.75%) pts, grade II – in 8 (25%), grade III – in 8 (25%), grade IV – in 4 (12.5%). At BL rSI was registered in 14 (43.75%) patients, after 7 years the number of patients with rSI increased to 20 (62.5%). At BL and 7 years follow-up r-sSI was detected in 10 (31.3%) and 16 (50%) pts (p=0.128). On each side X-SIJ progression was detected in 15 (46.9%) pts (at 1 grade – in 10, 2 grades – in 1, 3 grades – in 4), 1 patient showed a decrease at 1 grade (from III to II).Conclusion. In ePsA radiographic progression of SI is slow. Dactylitis, high CRP, and lack of iTNF-α therapy are associated with radiographic progression.