中性粒细胞-淋巴细胞和白蛋白-球蛋白比率与接受新辅助化疗或前期手术的乳腺癌患者预后的相关性

IF 2.2 4区 医学 Q3 ONCOLOGY Journal of Breast Cancer Pub Date : 2024-04-01 Epub Date: 2024-02-22 DOI:10.4048/jbc.2023.0242
Shi Hui Yang, Min Li Tey, Siqin Zhou, Phyu Nitar, Hanis Mariyah, Yirong Sim, Grace Kusumawidjaja, Wen Yee Chay, Wong Fuh Yong, Ru Xin Wong
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引用次数: 0

摘要

目的:较高的中性粒细胞-淋巴细胞比率(NLRs)表明一种促炎症状态,并与生存率低有关。相反,较高的白蛋白-球蛋白比值(AGR)可能与预后改善有关。我们旨在研究 NLR 和 AGR 与乳腺癌患者预后和生存期之间的关系:这项回顾性研究纳入了2011年至2017年期间在新加坡中央医院和新加坡国立癌症中心就诊的所有I-III期乳腺癌患者。对NLR、AGR、年龄、分期、分级和亚型进行了多变量逻辑回归分析。使用 Cox 回归分析和对数秩检验比较了各组间的生存数据:共纳入 1,188 例患者,其中 323 例接受了新辅助化疗 (NACT),865 例接受了前期手术。在接受 NACT 的患者中,较高的 AGR 与较高的 pCR 率显著相关(临界值 > 1.28;几率比 [OR],2.03;95% 置信区间 [CI],1.13-3.74;P = 0.020)。74; p = 0.020)、更好的 DFS(截断点 > 1.55; 危险比 [HR], 0.37; 95% CI, 0.16-0.85; p = 0.019)和更好的 CSS(截断点 > 1.46; HR, 0.39; 95% CI, 0.17-0.92; p = 0.031)。较高的 NLR 与较差的 DFS(切点 > 4.09;HR,1.77;95% CI,1.07-2.91;p = 0.026)和较差的 CSS(切点 > 4.09;HR,1.98;95% CI,1.11-3.53;p = 0.021)明显相关。在接受前期手术的患者中,较高的AGR与较好的OS相关(临界值>1.17;HR,0.54;95% CI,0.36-0.82;p = 0.004),较高的NLR与较差的OS相关(临界值>2.38;HR,1.63;95% CI,1.09-2.44;p = 0.018):结论:NLR和AGR有助于预测乳腺癌患者对NACT的反应和预后。需要进一步的研究来探讨它们在临床决策中的价值。
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Correlation of Neutrophil-Lymphocyte and Albumin-Globulin Ratios With Outcomes in Patients With Breast Cancer Undergoing Neoadjuvant Chemotherapy or Upfront Surgery.

Purpose: Higher neutrophil-lymphocyte ratio (NLRs) indicate a pro-inflammatory state and are associated with poor survival. Conversely, higher albumin-globulin ratio (AGRs) may be associated with improved prognosis. We aimed to investigate the association between NLR and AGR and prognosis and survival in patients with breast cancer.

Methods: This retrospective study included all patients with stage I-III breast cancer between 2011 and 2017 in Singapore General Hospital and National Cancer Center Singapore. Multivariate logistic regression analysis of NLR, AGR, age, stage, grade, and subtype was performed. Survival data between groups were compared using Cox regression analysis and log-rank tests.

Results: A total of 1,188 patients were included, of whom 323 received neoadjuvant chemotherapy (NACT) and 865 underwent upfront surgery. In patients who underwent NACT, a higher AGR was significantly associated with a higher pCR rate (cut-off > 1.28; odds ratio [OR], 2.03; 95% confidence interval [CI], 1.13-3.74; p = 0.020), better DFS (cut off > 1.55; hazard ratio [HR], 0.37; 95% CI, 0.16-0.85; p = 0.019), and better CSS (cut off > 1.46; HR, 0.39; 95% CI, 0.17-0.92; p = 0.031). Higher NLR was significantly associated with worse DFS (cut off > 4.09; HR, 1.77; 95% CI, 1.07-2.91; p = 0.026) and worse CSS (cut off > 4.09; HR, 1.98; 95% CI, 1.11-3.53; p = 0.021). In patients who underwent upfront surgery, higher AGR correlated with significantly better OS (cut off > 1.17; HR, 0.54; 95% CI, 0.36-0.82; p = 0.004) and higher NLR correlated with worse OS (cut off > 2.38; HR, 1.63; 95% CI, 1.09-2.44; p = 0.018).

Conclusion: NLR and AGR are useful in predicting the response to NACT as well as prognosis of patients with breast cancer. Further studies are needed to explore their value in clinical decision making.

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来源期刊
Journal of Breast Cancer
Journal of Breast Cancer 医学-肿瘤学
CiteScore
3.80
自引率
4.20%
发文量
43
审稿时长
6-12 weeks
期刊介绍: The Journal of Breast Cancer (abbreviated as ''J Breast Cancer'') is the official journal of the Korean Breast Cancer Society, which is issued quarterly in the last day of March, June, September, and December each year since 1998. All the contents of the Journal is available online at the official journal website (http://ejbc.kr) under open access policy. The journal aims to provide a forum for the academic communication between medical doctors, basic science researchers, and health care professionals to be interested in breast cancer. To get this aim, we publish original investigations, review articles, brief communications including case reports, editorial opinions on the topics of importance to breast cancer, and welcome new research findings and epidemiological studies, especially when they contain a regional data to grab the international reader''s interest. Although the journal is mainly dealing with the issues of breast cancer, rare cases among benign breast diseases or evidence-based scientifically written articles providing useful information for clinical practice can be published as well.
期刊最新文献
Breast Cancer Statistics in Korea, 2021. Characteristics and Prognosis of Breast Cancer Patients With Prior Hormone Replacement Therapy: Insights From the Korean Breast Cancer Society Registry. Prevalence of Programmed Death-Ligand 1 Positivity Using SP142 in Patients With Advanced Stage Triple-Negative Breast Cancer in Malaysia: A Cross-Sectional Study. Capsular Contracture After Postmastectomy Radiation in Implant-Based Breast Reconstruction: Effect of Implant Pocket and Two-Stage Surgery. Clinicopathological Features and Oncological Outcomes of Germline Partner and Localizer of Breast Cancer 2-Mutated Breast Cancer in Korea.
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